Ni-catalyzed reductive decyanation of nitriles with ethanol as the reductant

被引：6

作者：

Wu, Ke ^{[1
]}

Ling, Yichen ^{[1
]}

Sun, Nan ^{[1
]}

Hu, Baoxiang ^{[1
]}

Shen, Zhenlu ^{[1
]}

Jin, Liqun ^{[1
,2
]}

Hu, Xinquan ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 18期

关键词：

Ethanol - Cyanides - Catalysis - Amides - Aromatic compounds;

D O I：

10.1039/d0cc07743g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nickel-catalyzed reductive decyanation of aromatic nitriles has been developed, in which the readily available and abundant ethanol was applied as the hydride donor. Various functional groups on the aromatic rings, such as alkoxyl, amino, imino and amide, were compatible in this catalytic protocol. Heteroaryl, benzylic and alkenyl nitriles were also tolerated. Mechanistic investigation indicated that ethanol provided hydride efficiently via beta-hydride elimination in this reductive decyanation.

引用

页码：2273 / 2276

页数：4

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