ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

被引:6
|
作者
Serrano-Garrido, Orlando [1 ,2 ]
Peris-Torres, Carlos [1 ]
Redondo-Garcia, Silvia [1 ]
Asenjo, Helena G. [1 ]
Plaza-Calonge, Maria del Carmen [1 ]
Fernandez-Luna, Jose Luis [3 ]
Rodriguez-Manzaneque, Juan Carlos [1 ]
机构
[1] Univ Granada, Ctr Genom & Oncol Res Pfizer, Junta Andalucia, GENYO, Ave Ilustrac,114, Granada 18016, Spain
[2] Univ Panama, Fac Med, Ciudad Univ, Panama City 3366, Panama
[3] Hosp Univ Marques Valdecilla, Mol Genet Unit, Ave Valdecilla,S-N, Santander 39008, Spain
关键词
ADAMTS proteases; endothelial-like phenotype; extracellular metalloprotease; glioblastoma; plasticity;
D O I
10.3390/biom11010044
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gliomas in general and the more advanced glioblastomas (GBM) in particular are the most usual tumors of the central nervous system with poor prognosis. GBM patients develop resistance to distinct therapies, in part due to the existence of tumor cell subpopulations with stem-like properties that participate in trans-differentiation events. Within the complex tumor microenvironment, the involvement of extracellular proteases remains poorly understood. The extracellular protease ADAMTS1 has already been reported to contribute to the plasticity of cancer cells. Accordingly, this basic knowledge and the current availability of massive sequencing data from human gliomas, reinforced the development of this work. We first performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established GBM cells with the ability to acquire an endothelial-like phenotype. Using a co-culture approach of endothelial and GBM cells, we noticed a relevant function of ADAMTS1 in GBM cells leading the organization of endothelial-like networks and, even more significantly, we found a blockade of the formation of tumor-spheres and a deficient response to hypoxia in the absence of ADAMTS1. Our data support a chief role of this protease modulating the phenotypic plasticity of GBM.
引用
收藏
页码:1 / 17
页数:17
相关论文
共 50 条
  • [41] Exosomes Secreted by Inflammatory Cytokine Stimulated Glioma Cells Carry a Repertoire of Proteins Which Influence Progression of Glioblastoma Multiforme
    Kore, Rajshekhar A.
    Abraham, Edathara C.
    Griffin, Robert J.
    FASEB JOURNAL, 2016, 30
  • [42] Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats
    Diamantis, I
    Lüthi, M
    Hösli, M
    Reichen, J
    LIVER, 2000, 20 (02): : 165 - 172
  • [43] Notch1 Activation in Endothelial Cells Promotes Progression of Atherosclerosis
    Liu, Zhao-Jun
    Li, Yan
    Zhang, Leiming
    Regueiro, Manuela M.
    Wei, Yuntao
    Velazquez, Omaida C.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38
  • [44] CIRCULATING ENDOTHELIAL CELLS IN THE PERIPHERAL BLOOD OF PATIENTS WITH GLIOBLASTOMA AT THE TIME OF PROGRESSION AFTER TREATMENT WITH RESECTION AND ADJUVANT CHEMORADIOTHERAPY
    Stockham, Abigail L.
    Borden, Ernest
    Peereboom, David
    NEURO-ONCOLOGY, 2011, 13 : 4 - 4
  • [45] Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1
    Zhang, Yanbin
    Lv, Peng
    Zhang, Qing
    Xiang, Wei
    Jiang, Xiaobing
    Guo, Zijun
    Zhang, Tao
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [46] RBMS1 interference inhibits malignant progression of glioblastoma cells and promotes ferroptosis
    Liang, Xiaosong
    Wang, Gang
    Xue, Chunxiao
    Zhou, Yifu
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [47] Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells
    Castruccio Castracani, Carlo
    Longhitano, Lucia
    Distefano, Alfio
    Di Rosa, Michelino
    Pittala, Valeria
    Lupo, Gabriella
    Caruso, Massimo
    Corona, Daniela
    Tibullo, Daniele
    Li Volti, Giovanni
    MOLECULAR NEUROBIOLOGY, 2020, 57 (05) : 2436 - 2446
  • [48] Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells
    Carlo Castruccio Castracani
    Lucia Longhitano
    Alfio Distefano
    Michelino Di Rosa
    Valeria Pittalà
    Gabriella Lupo
    Massimo Caruso
    Daniela Corona
    Daniele Tibullo
    Giovanni Li Volti
    Molecular Neurobiology, 2020, 57 : 2436 - 2446
  • [49] Blockade of radiation-induced neuropilin-1 in glioblastoma cells impairs migration of endothelial cells
    Maddirela, Dilip Rajasekhar
    Kesanakurti, Divya
    Gogineni, Venkateswara R.
    Chetty, Chandramu
    CANCER RESEARCH, 2014, 74 (19)
  • [50] Study of the Glioma Initiating Cells CD44high/ID1high in Glioblastoma
    Gonzalez Junca, A.
    Sanchez-Redondo, S.
    Cuartas, I.
    Seoane, J.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S112 - S112