Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria

被引：8
|
作者：
Shimbashi, Akiko [1 ]
Nishiyama, Shigeru [1 ]
机构：
[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 09期
关键词：
chloroquinocin; methicillin-resistant Staphylococcus aureus; antibiotic; gram-positive bacteria; pyranonaphthoquinone; chlorination;
D O I：
10.1016/j.tetlet.2007.01.020
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1545 / 1548
页数：4
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