Voltammetric responsive sensors for organic compounds based on organized self-assembled lipoyl-beta-cyclodextrin derivative monolayer on a gold electrode

Voltammetric responsive sensors based on organized self-assembled beta-cyclodextrin derivative monolayers on a gold electrode (beta-CD-SME) for electroinactive organic species were studied. Both theoretical considerations and experimental results proved that the reduction in the oxidation peak current of the electroactive marker, ferrocene caboxylic acid, at beta-CD-SME was proportional to the concentration of the target molecule and the formation constant of the inclusion complexes with beta-CD. The application of the sensor as a detector for ursodeoxycholic and dehydrocholic acids after capillary electrophoresis (CE) separation has been tested. This sensor provides an alternative approach for the detection of electroinactive organic species, and is expected to find application in liquid chromatography (LC) and CE detection.