A study of multinucleated giant cells in esophageal cancer

被引：9

作者：

Wang, Hui ^{[1
]}

Zhou, Junjie ^{[3
]}

Li, Jun ^{[4
]}

Geng, Yiqun ^{[1
]}

Meng, Pei ^{[9
]}

Ma, Changchun ^{[5
]}

Zhu, Ziqi ^{[1
]}

Zhang, Weifeng ^{[1
]}

Hong, Liangli ^{[1
]}

Quan, Yan ^{[1
]}

Wei, Jiacong ^{[6
]}

Huang, Qiongyi ^{[7
]}

Zhou, You ^{[3
]}

Su, Zuoqing ^{[1
]}

Zhu, Xiaoqing ^{[1
]}

Chen, Chuangzhen ^{[5
]}

Chen, Shaobin ^{[8
]}

Gu, Jiang ^{[1
,2
]}

机构：

[1] Shantou Univ, Ctr Collaborat & Creat Ctr, Dept Pathol & Pathophysiol, Prov Key Lab Mol Pathol & Personalized Med,Med Co, Shantou, Guangdong, Peoples R China

[2] Jinjiang Hosp Maternal & Child Hlth Care, Jinxin Res Inst Reprod Med & Genet, 66 Jingxiu Rd, Chengdu, Peoples R China

[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan, Hubei, Peoples R China

[4] Univ Hong Kong, Div Hepatobiliary & Pancreat Surg, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China

[5] Shantou Univ, Affiliated Canc Hosp, Dept Radiat Oncol, Med Coll, Shantou, Guangdong, Peoples R China

[6] Chinese Acad Med Sci, Dept Pathol, Canc Hosp, Beijing, Peoples R China

[7] Tongji Univ, Shanghai Peoples Hosp 10, Dept Pathol, Shanghai, Peoples R China

[8] Shantou Univ, Affiliated Canc Hosp, Dept Thorac Surg, Med Coll, Shantou, Guangdong, Peoples R China

[9] Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Holland, Netherlands

来源：

CLINICAL IMMUNOLOGY | 2021年 / 222卷

基金：

中国国家自然科学基金;

关键词：

MGC; Macrophage polarization; Phagocytosis; Esophageal cancer; Prognosis; TUMOR-ASSOCIATED MACROPHAGES; IGG-FC; PROGRESSION; COMPLEMENT; MATRIX-METALLOPROTEINASE-9; POLARIZATION; ACTIVATION; EXPRESSION; PLASTICITY; RECEPTORS;

D O I：

10.1016/j.clim.2020.108600

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objectives: To evaluate the occurrence, abundance, distribution, nature and clinical significance of multi-nucleated giant cell (MGC) in esophageal cancer. Materials and methods: MGCs were examined with conventional pathology, immunohistochemistry and immunofluorescence in 107 esophageal cancer tissues. The findings were correlated to pathological diagnosis and clinical behavior of the cancers. Results: MGCs were identified in 31.7% (34/107) of the cases. MGCs were positive for CD11c, CD11b, CD32, CD16, HLA-DR and MMP9, and negative for CD163, CD206 and CD64 giving a molecular profile of proinflammatory M1 but not immunosuppressive M2. MGCs were significantly related to decreased lymph node metastasis (p = 0.011), low pTNM stage (p = 0.044), favorable survival (p = 0.04), squamous cell cancer type rather than other histopathological subtypes (p = 0.020) and associated to better differentiation (p = 0.063). Conclusions: MGCs belong to M1 macrophage and perform phagocytosis and scavenging of cancer cells that would benefit patients' survival and could serve as a prognostic marker.

引用

页数：8

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