Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines

被引：0
|
作者：
Rahman, MA [1 ]
Dhar, DK [1 ]
Masunaga, R [1 ]
Yamanoi, A [1 ]
Kohno, H [1 ]
Nagasue, N [1 ]
机构：
[1] Shimane Med Univ, Dept Surg 2, Izumo, Shimane 693, Japan
来源：
CANCER RESEARCH | 2000年 / 60卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer cell lines. The growth inhibition and cytotoxicity of sulindac in human hepatocellular carcinoma cell lines HepG2, Huh-7, and KYN-2 were investigated by studying cell growth, cell cycle distribution, and induction of apoptosis. In the presence of sulindac, there was a marked time- and dose-dependent decrease in cell proliferation and viability. Also, exisulind exhibited a similar growth-inhibitory effect on the KYN-2 cell line. The findings of this study suggest that sulindac exhibits a growth-inhibitory effect on human hepatocellular carcinoma cell lines; therefore, these drugs might serve as an effective tool for hepatocellular carcinoma chemoprevention.
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页码：2085 / 2089
页数：5
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