Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines

被引：0

作者：

Rahman, MA ^{[1
]}

Dhar, DK ^{[1
]}

Masunaga, R ^{[1
]}

Yamanoi, A ^{[1
]}

Kohno, H ^{[1
]}

Nagasue, N ^{[1
]}

机构：

[1] Shimane Med Univ, Dept Surg 2, Izumo, Shimane 693, Japan

来源：

CANCER RESEARCH | 2000年 / 60卷 / 08期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer cell lines. The growth inhibition and cytotoxicity of sulindac in human hepatocellular carcinoma cell lines HepG2, Huh-7, and KYN-2 were investigated by studying cell growth, cell cycle distribution, and induction of apoptosis. In the presence of sulindac, there was a marked time- and dose-dependent decrease in cell proliferation and viability. Also, exisulind exhibited a similar growth-inhibitory effect on the KYN-2 cell line. The findings of this study suggest that sulindac exhibits a growth-inhibitory effect on human hepatocellular carcinoma cell lines; therefore, these drugs might serve as an effective tool for hepatocellular carcinoma chemoprevention.

引用

页码：2085 / 2089

页数：5

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