The NIH Human Microbiome Project

被引：1350

作者：

Peterson, Jane ^{[1
]}

Garges, Susan ^{[2
]}

Giovanni, Maria

McInnes, Pamela ^{[1
,3
]}

Wang, Lu ^{[1
]}

Schloss, Jeffery A. ^{[1
]}

Bonazzi, Vivien ^{[1
]}

McEwen, Jean E. ^{[1
]}

Wetterstrand, Kris A.

Deal, Carolyn ^{[2
]}

Baker, Carl C. ^{[4
]}

Di Francesco, Valentina ^{[2
]}

Howcroft, T. Kevin ^{[5
]}

Karp, Robert W. ^{[6
]}

Lunsford, R. Dwayne ^{[3
]}

Wellington, Christopher R. ^{[1
]}

Belachew, Tsegahiwot ^{[1
]}

Wright, Michael ^{[2
]}

Giblin, Christina ^{[2
]}

David, Hagit ^{[2
]}

Mills, Melody ^{[2
]}

Salomon, Rachelle ^{[2
]}

Mullins, Christopher ^{[6
]}

Akolkar, Beena ^{[6
]}

Begg, Lisa ^{[7
]}

Davis, Cindy ^{[5
]}

Grandison, Lindsey ^{[8
]}

Humble, Michael ^{[9
]}

Khalsa, Jag ^{[10
]}

Little, A. Roger ^{[11
]}

Peavy, Hannah ^{[12
]}

Pontzer, Carol ^{[13
]}

Portnoy, Matthew ^{[14
]}

Sayre, Michael H. ^{[15
]}

Starke-Reed, Pamela

Zakhari, Samir ^{[8
]}

Read, Jennifer ^{[3
,16
]}

Watson, Bracie ^{[17
]}

Guyer, Mark ^{[1
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] NIAID, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA

[4] NIAMSD, NIH, Bethesda, MD 20892 USA

[5] NCI, NIH, Bethesda, MD 20892 USA

[6] NIDDKD, NIH, Bethesda, MD 20892 USA

[7] NIH, Off Director, Bethesda, MD 20892 USA

[8] NIAAA, NIH, Bethesda, MD 20892 USA

[9] NIEHS, NIH, Bethesda, MD 20892 USA

[10] NIDA, NIH, Bethesda, MD 20892 USA

[11] NIMH, NIH, Bethesda, MD 20892 USA

[12] NHLBI, NIH, Bethesda, MD 20892 USA

[13] NIH, Natl Ctr Complementary & Alternat Med, Bethesda, MD 20892 USA

[14] NIGMS, NIH, Bethesda, MD 20892 USA

[15] NIH, Natl Ctr Res Resources, Bethesda, MD 20892 USA

[16] NICHHD, NIH, Bethesda, MD 20892 USA

[17] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD 20892 USA

来源：

GENOME RESEARCH | 2009年 / 19卷 / 12期

关键词：

MOLECULAR ANALYSIS; METAGENOMICS; DIVERSITY; COMMUNITY; SEQUENCE; CLONING;

D O I：

10.1101/gr.096651.109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: ( 1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 "normal'' volunteers; ( 2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and ( 3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.

引用

页码：2317 / 2323

页数：7

共 50 条

[31] Strains, functions and dynamics in the expanded Human Microbiome Project
Lloyd-Price, Jason
Mahurkar, Anup
Ahnavard, Gholamali R.
Rabtree, Jonathan C.
Rvis, Joshua O.
Hall, A. B. Rantley
Rady, Arthur B.
Reasy, Heather H. C.
McCracken, Carrie
Giglio, Michelle G.
McDonald, Daniel
Franzosa, Eric A.
Knight, Rob
White, Owen
Huttenhower, Curtis
NATURE, 2017, 550 (7674) : 61 - +
[32] The Human Microbiome Project: An Opportunity to Engage Undergraduates in Research
Rosenwald, Anne G.
Arora, Gaurav S.
Madupu, Ramana
Roecklein-Canfield, Jennifer
Russell, Janet S.
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE, ICCS 2012, 2012, 9 : 540 - 549
[33] A data analysis and coordination center for the human microbiome project
Jennifer Wortman
Michelle Giglio
Heather Creasy
Amy Chen
Konstantinos Liolios
Ken Chu
Noam Davidovics
Mark Mazaitis
Todd DeSantis
Navjeet Singh
Joshua Orvis
Jonathan Crabtree
Victor Felix
Catherine Jordan
Anup Mahurkar
Rob Knight
Gary Andersen
Nikos Kyrpides
Victor Markowitz
Owen White
Genome Biology, 11 (Suppl 1)
[34] The gut mycobiome of the Human Microbiome Project healthy cohort
Andrea K. Nash
Thomas A. Auchtung
Matthew C. Wong
Daniel P. Smith
Jonathan R. Gesell
Matthew C. Ross
Christopher J. Stewart
Ginger A. Metcalf
Donna M. Muzny
Richard A. Gibbs
Nadim J. Ajami
Joseph F. Petrosino
Microbiome, 5
[35] The human microbiome project and pharmaceutical quality control microbiology
Akers, James
Agalloco, James
Pharmaceutical Technology, 2015, 39 (04) : 48 - 59
[36] A Stoichioproteomic Analysis of Samples from the Human Microbiome Project
Vecchio-Pagan, Briana
Bewick, Sharon
Mainali, Kumar
Karig, David K.
Fagan, William F.
FRONTIERS IN MICROBIOLOGY, 2017, 8
[37] Human Microbiome Project - influence of gut microbiota on human physiology and health
Olszewska, Joanna
Jagusztyn-Krynicka, Elzbieta Katarzyna
POSTEPY MIKROBIOLOGII, 2012, 51 (04): : 243 - 256
[38] Human genome project - NIH to Produce a 'working draft' of the genome by 2001
Marshall, E
SCIENCE, 1998, 281 (5384) : 1774 - 1775
[39] NIH funds lipid project
不详
CHEMICAL & ENGINEERING NEWS, 2003, 81 (33) : 32 - 32
[40] NIH PREPARES FOR GENOME PROJECT
MCDONALD, A
SCIENTIST, 1988, 2 (06): : 6 - 6

← 1 2 3 4 5 →