Nevirapine levels after discontinuation of rifampicin therapy and 60-week efficacy of nevirapine-based antiretroviral therapy in HIV-infected patients with tuberculosis

被引：31
|
作者：
Manosuthi, Weerawat
Ruxrungtham, Kiat
Likanonsakul, Sirirat
Prasithsirikul, Wisit
Inthong, Yaowarat
Phoorisri, Thanongsri
Sungkanuparph, Somnuek
机构：
[1] Bamrasnaradura Infect Dis Inst, Minist Publ Hlth, Dept Med, Nonthaburi 11000, Thailand
[2] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok 10400, Thailand
[3] Chulalongkorn Univ, Bangkok, Thailand
[4] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand
来源：
CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 01期
关键词：
D O I：
10.1086/510078
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Seventy patients with human immunodeficiency virus (HIV) and tuberculosis coinfection who initiated nevirapine-based antiretroviral therapy and had trough nevirapine levels determined while receiving rifampicin were enrolled in a study. After discontinuation of rifampicin therapy, mean nevirapine levels (+/- standard deviation) increased from 5.4 +/- 3.5mg/L to 6.4 +/- 3.4mg/ L (P = .047), but no nevirapine-related adverse events occurred. There was no statistically significant difference in 60-week antiviral efficacy between these patients and patients receiving nevirapine-based antiretroviral therapy alone (P >.05).
引用
收藏
页码：141 / 144
页数：4
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