Opinion - Angiogenesis: an organizing principle for drug discovery?

被引：1750

作者：

Folkman, Judah ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 04期

关键词：

D O I：

10.1038/nrd2115

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Angiogenesis - the process of new blood-vessel growth - has an essential role in development, reproduction and repair. However, pathological angiogenesis occurs not only in tumour formation, but also in a range of nonneoplastic diseases that could be classed together as 'angiogenesis-dependent diseases'. By viewing the process of angiogenesis as an 'organizing principle' in biology, intriguing insights into the molecular mechanisms of seemingly unrelated phenomena might be gained. This has important consequences for the clinical use of angiogenesis inhibitors and for drug discovery, not only for optimizing the treatment of cancer, but possibly also for developing therapeutic approaches for various diseases that are otherwise unrelated to each other.

引用

页码：273 / 286

页数：14

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