Cell-Based Therapy for Ischemic Heart Disease: A Clinical Update

被引：39
|
作者：
Herrmann, Jeremy L.
Abarbanell, Aaron M.
Weil, Brent R.
Wang, Yue
Wang, Meijing
Tan, Jiangning
Meldrum, Daniel R.
机构：
[1] Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN USA
[3] Indiana Univ, Sch Med, Ctr Immunobiol, Indianapolis, IN USA
来源：
ANNALS OF THORACIC SURGERY | 2009年 / 88卷 / 05期
关键词：
MESENCHYMAL STEM-CELLS; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; STROMAL CELLS; MONONUCLEAR-CELLS; INTRACORONARY INJECTION; SKELETAL MYOBLASTS; PERIPHERAL-BLOOD;
D O I：
10.1016/j.athoracsur.2009.05.079
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Progenitor cell therapy is a promising treatment for ischemic heart disease. Early clinical trials of autologous bone marrow-derived progenitor cell therapy for acute and chronic myocardial ischemia showed modest functional improvements after cell delivery; however, the duration of these benefits remains unclear. Ongoing investigations continue to enhance our understanding of the mechanisms by which progenitor and stem cells function and how their survival and cardioprotective abilities can be improved. This review discusses: (1) relevant progenitor and stem cells in myocardial regenerative therapy, (2) routes of cell delivery to ischemic myocardium, (3) clinical trials investigating bone marrow-derived progenitor cell therapy for myocardial ischemia, and (4) future directions of the field. (Ann Thorac Surg 2009; 88: 1714-22) (C) 2009 by The Society of Thoracic Surgeons
引用
收藏
页码：1714 / 1722
页数：9
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