Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN

被引：52

作者：

Piel, Clement ^{[1
]}

Pouchieu, Camille ^{[1
,2
]}

Carles, Camille ^{[1
,3
]}

Beziat, Beatrix ^{[1
]}

Boulanger, Mathilde ^{[4
,5
,6
]}

Bureau, Mathilde ^{[1
]}

Busson, Amandine ^{[4
,5
,6
]}

Gruber, Anne ^{[1
]}

Lecluse, Yannick ^{[4
,5
,6
]}

Migault, Lucile ^{[1
]}

Renier, Marine ^{[4
,5
,6
]}

Rondeau, Virginie ^{[1
]}

Schwall, Xavier ^{[1
]}

Tual, Severine ^{[4
,5
,6
]}

Arveux, P. ^{[27
]}

Bara, S. ^{[7
]}

Bouvier, A. M. ^{[8
]}

Busquet, T. ^{[9
]}

Colonna, M. ^{[10
]}

Coureau, G. ^{[11
]}

Delanoe, M. ^{[12
]}

Grosclaude, P. ^{[28
]}

Guizard, A., V ^{[29
]}

Herbrecht, P. ^{[13
]}

Laplante, J. J. ^{[14
]}

Lapotre-Ledoux, B. ^{[15
]}

Launoy, G. ^{[16
]}

Lenoir, D. ^{[17
]}

Marrer, E. ^{[18
]}

Marcotullio, E. ^{[19
]}

Maynadie, M. ^{[20
]}

Molinie, F. ^{[21
]}

Monnereau, A. ^{[22
]}

Paumier, A. ^{[23
]}

Pouzet, P. ^{[30
]}

Thibaudier, J. M. ^{[24
]}

Troussard, X. ^{[25
]}

Velten, M. ^{[26
]}

Wavelet, E. ^{[31
]}

Woronoff, A. S. ^{[32
]}

Lebaillyd, Pierre ^{[4
,5
,6
]}

Baldia, Isabelle ^{[1
,2
,3
]}

机构：

[1] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, EPICENE Team, ISPED,INSERM,U1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[2] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Registre Tumeurs Primit Syst Nerveux Cent Gironde, ISPED,Ctr INSERM,U1219, Bordeaux, France

[3] CHU Bordeaux, Serv Med Travail & Pathol Profess, Bordeaux, France

[4] INSERM, U1086 Anticipe Axe Canc & Prevent, Caen, France

[5] Univ Caen Normandie, Caen, France

[6] Ctr Lutte Canc Francois Baclesse, Caen, France

[7] Registre Gen Canc Manche, Octeville, France

[8] Registre Bourguignon Canc Digestifs, Dijon, France

[9] MSA Gironde, Bordeaux, France

[10] Registre Gen Canc Isere, Grenoble, France

[11] Registre Gen Canc Gironde, Bordeaux, France

[12] MSA Midi Pyrenees Nord, Rodez, France

[13] MSA Alsace, Colmar, France

[14] MSA Franche Comte, Besancon, France

[15] Registre Gen Canc Somme, Amiens, France

[16] Registre Tumeurs Digest Calvados, Caen, France

[17] MSA Bourgogne, Dijon, France

[18] Registre Gen Canc Haut Rhin, Mulhouse, France

[19] Caisse Cent MSA, Bobigny, France

[20] Registre Hemopathies Malignes Cote Or, Dijon, France

[21] Registre Gen Loire Atlantique & Vendee, Nantes, France

[22] Registre Hemopathies Malignes Gironde, Bordeaux, France

[23] MSA Picardie, Beauvais, France

[24] MSA Alpes Nord, Chambery, France

[25] Registre Reg Hemopathies Malignes Basse Normandie, Caen, France

[26] Registre Gen Canc Bas Rhin, Strasbourg, France

[27] Registre Canc Sein & Canc Gynecol Cote Or, Dijon, France

[28] Registre Gen Canc Tarn, Albi, France

[29] Registre Gen Tumeurs Calvados, Caen, France

[30] MSA Coes Normandes, Caen, France

[31] MSA Loire Atlantique Vendee, St Herblain, France

[32] Registre Gen Tumeurs Doubs, Besancon, France

来源：

ENVIRONMENT INTERNATIONAL | 2019年 / 130卷

关键词：

Carbamates; Thiocarbamates; Dithiocarbamates; Herbicides; Fungicides; CNS tumors; Occupational exposure; Risk factors; Cohort studies; FARM PESTICIDE EXPOSURE; OCCUPATIONAL-EXPOSURE; CANCER RISK; HEALTH; GLIOMAS; APPLICATORS; MEN;

D O I：

10.1016/j.envint.2019.05.070

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype. Methods: AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking. Results: During an average follow-up of 6.9 years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR = 1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR = 1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans. Conclusions: Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides.

引用

页数：11

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