Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses

被引:25
|
作者
Hart, Carl L.
Haney, Margaret
Collins, Eric D.
Rubin, Eric
Foltin, Richard W.
机构
[1] Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Div Subst Abuse, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[3] Columbia Univ, Dept Psychol, New York, NY 10027 USA
关键词
cocaine; gabapentin; Neurotin (R); GABA; humans; mood;
D O I
10.1016/j.drugalcdep.2006.05.028
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Previously, we reported that gabapentin, a X-aminobutyric acid (GABA) agonist, significantly reduced "positive" subjective effects of cocaine without reducing cocaine self-administration. We speculated that the gabapentin doses used in that study were too low to detect subtle shifts in the reinforcing effects of cocaine. Thus, the present study examined the effects of larger gabapentin maintenance doses on cocaine-related effects, including self-administration. During this 48-day double-blind, crossover design study, the effects of gabapentin maintenance (0, 2400, 3200 mg/day) on response to cocaine (0, 12, 25, 50 mg) were investigated in six cocaine-dependent individuals not seeking treatment for their cocaine use. Active cocaine significantly increased choice to self-administer cocaine, subjective-effect ratings (e.g., "Good Drug Effect"), blood pressure, and heart rate. Gabapentin did not decrease cocaine self-administration, cardiovascular measures, or most subjective effects of cocaine. These data agree with findings from a clinical trial examining the effects of similar gabapentin doses on cocaine use by treatment-seeking cocaine-dependent individuals and suggest that gabapentin does not show promise as a treatment medication for cocaine dependence. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:274 / 277
页数:4
相关论文
共 50 条
  • [21] Binge cocaine self-administration in humans: intravenous cocaine
    A. S. Ward
    Margaret Haney
    Marian W. Fischman
    Richard W. Foltin
    [J]. Psychopharmacology, 1997, 132 : 375 - 381
  • [22] Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases
    Angarita, Gustavo A.
    Pittman, Brian
    Gueorguieva, Ralitza
    Kalayasiri, Rasmon
    Lynch, Wendy J.
    Sughondhabirom, Atapol
    Morgan, Peter T.
    Malison, Robert T.
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2010, 95 (01) : 51 - 55
  • [23] Smoked cocaine self-administration in females and voucher incentives for abstinence
    Evans, SM
    Levin, FR
    Fischman, MW
    Foltin, RW
    [J]. JOURNAL OF SUBSTANCE ABUSE, 1998, 10 (02) : 143 - 162
  • [24] EFFECTS OF BUPRENORPHINE ON THE SELF-ADMINISTRATION OF COCAINE BY HUMANS
    FOLTIN, RW
    FISCHMAN, MW
    [J]. BEHAVIOURAL PHARMACOLOGY, 1994, 5 (01): : 79 - 89
  • [25] SELF-ADMINISTRATION OF COCAINE BY HUMANS - A LABORATORY PERSPECTIVE
    FISCHMAN, MW
    FOLTIN, RW
    [J]. CIBA FOUNDATION SYMPOSIA, 1992, 166 : 165 - 180
  • [26] Effects of phenytoin on cocaine self-administration in humans
    Sofuoglu, M
    Pentel, PR
    Bliss, RL
    Goldman, AI
    Hatsukami, DK
    [J]. DRUG AND ALCOHOL DEPENDENCE, 1999, 53 (03) : 273 - 275
  • [27] Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans
    Margaret Haney
    Amie S. Ward
    Richard W. Foltin
    Marian W. Fischman
    [J]. Psychopharmacology, 2001, 155 : 330 - 337
  • [28] Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans
    Haney, M
    Ward, AS
    Foltin, RW
    Fischman, MW
    [J]. PSYCHOPHARMACOLOGY, 2001, 155 (04) : 330 - 337
  • [29] Effects of oral THC maintenance on smoked marijuana self-administration
    Hart, CL
    Haney, M
    Ward, AS
    Fischman, MW
    Foltin, RW
    [J]. DRUG AND ALCOHOL DEPENDENCE, 2002, 67 (03) : 301 - 309
  • [30] Regulation of Cocaine Self-Administration in Humans: Lack of Evidence for Distinct Loading and Maintenance Phases
    Angarita, Gustavo A.
    Pittman, Brian
    Gueorguieva, Ralitza
    Kalayasiri, Rasmon
    Lynch, Wendy J.
    Sughondhabirom, Atapol
    Morgan, Peter T.
    Malison, Robert T.
    [J]. BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 117S - 117S