Synthesis of unsaturated 1,4-heteroatom-containing benzo-fused heterocycles using a sequential isomerization-ring-closing metathesis strategy

被引：28

作者：

Morgans, Garreth L. ^{[1
]}

Ngidi, E. Lindani ^{[1
]}

Madeley, Lee G. ^{[1
]}

Khanye, Setshaba D. ^{[1
]}

Michael, Joseph P. ^{[1
]}

de Koning, Charles B. ^{[1
]}

van Otterlo, Willem A. L. ^{[1
]}

机构：

[1] Univ Witwatersrand, Sch Chem, Inst Mol Sci, ZA-2050 Johannesburg, South Africa

来源：

TETRAHEDRON | 2009年 / 65卷 / 51期

基金：

新加坡国家研究基金会;

关键词：

Ring-closing metathesis; Isomerization; 1,4-Benzodioxins; 4H-1,4-Benzoxazines; Benzodithiin; 1,4-Benzoxathiin; DOUBLE-BOND MIGRATION; OPENING/CROSS-METATHESIS; NORBORNENE DERIVATIVES; RUTHENIUM CARBENE; RECEPTOR AGONISTS; SYSTEMS; ALLYL; COMPLEXES; CATALYSTS; 1,4-BENZODIOXINS;

D O I：

10.1016/j.tet.2009.10.061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A small library of 1,4-benzodioxins and 4H-1,4-benzoxazines was synthesized from the corresponding bis-allyloxy precursors by way of an initial isomerization to the bis-vinyloxy compounds, followed by a ring-closing metathesis using the second generation Grubbs' catalyst (G2). A related strategy, starting from benzene-1,2-dithiol and 2-mercaptophenol, afforded benzodithiin and 1,4-benzoxathiin, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：10650 / 10659

页数：10

共 29 条

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