Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology

被引：240

作者：

Hartmann, Karin ^{[1
,2
]}

Escribano, Luis ^{[3
,4
,5
]}

Grattan, Clive ^{[6
]}

Brockow, Knut ^{[7
]}

Carter, Melody C. ^{[8
]}

Alvarez-Twose, Ivan ^{[9
]}

Matito, Almudena ^{[9
]}

Broesby-Olsen, Sigurd ^{[10
,11
]}

Siebenhaar, Frank ^{[13
]}

Lange, Magdalena ^{[14
]}

Niedoszytko, Marek ^{[15
]}

Castells, Mariana ^{[16
]}

Oude Elberink, Joanna N. G. ^{[17
]}

Bonadonna, Patrizia ^{[18
]}

Zanotti, Roberta ^{[19
]}

Hornick, Jason L. ^{[20
]}

Torrelo, Antonio ^{[22
]}

Grabbe, Juergen ^{[23
]}

Rabenhorst, Anja ^{[1
]}

Nedoszytko, Boguslaw ^{[14
]}

Butterfield, Joseph H. ^{[21
,24
]}

Gotlib, Jason ^{[25
]}

Reiter, Andreas ^{[26
]}

Radia, Deepti ^{[27
]}

Hermine, Olivier ^{[28
]}

Sotlar, Karl ^{[29
]}

George, Tracy I. ^{[30
]}

Kristensen, Thomas K. ^{[12
]}

Kluin-Nelemans, Hanneke C. ^{[31
]}

Yavuz, Selim ^{[32
]}

Hagglund, Hans ^{[33
]}

Sperr, Wolfgang R. ^{[34
]}

Schwartz, Lawrence B. ^{[35
]}

Triggiani, Massimo ^{[36
]}

Maurer, Marcus ^{[13
]}

Nilsson, Gunnar ^{[37
]}

Horny, Hans-Peter ^{[29
]}

Arock, Michel ^{[38
]}

Orfao, Alberto ^{[3
,4
,5
]}

Metcalfe, Dean D. ^{[8
]}

Akin, Cem ^{[16
]}

Valent, Peter ^{[34
]}

机构：

[1] Univ Cologne, Dept Dermatol, Cologne, Germany

[2] Med Univ Lubeck, Dept Dermatol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[3] Univ Salamanca, Serv Cent Citometria NUCLEUS, Ctr Invest Canc IBMCC, CSIC USAL, E-37008 Salamanca, Spain

[4] Univ Salamanca, Dept Med, E-37008 Salamanca, Spain

[5] Univ Salamanca, IBSAL, E-37008 Salamanca, Spain

[6] Norfolk & Norwich Univ Hosp, Norwich, Norfolk, England

[7] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, D-80290 Munich, Germany

[8] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA

[9] Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, Toledo, Spain

[10] Odense Univ Hosp, Dept Dermatol, Odense, Denmark

[11] Odense Univ Hosp, Allergy Ctr, Odense, Denmark

[12] Odense Univ Hosp, Dept Pathol, Odense, Denmark

[13] Charite Univ Med Berlin, Dept Dermatol & Allergy, Interdisciplinary Mastocytosis Ctr Charite, Berlin, Germany

[14] Med Univ Gdansk, Dept Dermatol Venereol & Allergol, Gdansk, Poland

[15] Med Univ Gdansk, Dept Allergol, Gdansk, Poland

[16] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[17] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD, Dept Allergol, NL-9700 AB Groningen, Netherlands

[18] Verona Univ Hosp, Allergy Unit, Verona, Italy

[19] Verona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy

[20] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[21] Harvard Med Sch, Boston, MA USA

[22] Hosp Nino Jesus, Dept Dermatol, Madrid, Spain

[23] Cantonal Hosp Aarau, Dept Dermatol, Aarau, Switzerland

[24] Mayo Clin, Div Allerg Dis, Rochester, MN USA

[25] Stanford Univ, Sch Med, Div Hematol, Dept Med, Stanford, CA 94305 USA

[26] Heidelberg Univ, Med Klin 3, Univ Med Mannheim, Mannheim, Germany

[27] Guys & St Thomas NHS Fdn Trust, Guys Hosp, Dept Haematol, London, England

[28] Univ Paris 05, Sorbonne Paris Cite, Natl Reference Ctr Mastocytosis,Imaging Inst, Dept Hematol,INSERM U1163,CNRS ERL8564, Paris, France

[29] Univ Munich, Inst Pathol, D-80539 Munich, Germany

[30] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA

[31] Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, NL-9700 AB Groningen, Netherlands

[32] Istanbul Univ, Dept Internal Med, Div Hematol, Istanbul, Turkey

[33] Karolinska Univ Hosp, Hematol Ctr Karolinska, Stockholm, Sweden

[34] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[35] Virginia Commonwealth Univ, Med Coll Virginia, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA 23298 USA

[36] Univ Salerno, Div Clin Immunol & Allergy, Salerno, Italy

[37] Karolinska Inst, Dept Med, Clin Immunol & Allergy, Stockholm, Sweden

[38] Ecole Normale Super, Mol Oncol & Pharmacol, LBPA CNRS UMR8113, Cachan, France

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2016年 / 137卷 / 01期

关键词：

Classification; cutaneous mastocytosis; diagnostic criteria; mast cell; mastocytosis; standardization; urticaria pigmentosa; MAST-CELLS; PEDIATRIC MASTOCYTOSIS; URTICARIA PIGMENTOSA; SYSTEMIC MASTOCYTOSIS; ONSET MASTOCYTOSIS; DIAGNOSTIC-CRITERIA; GERMLINE MUTATION; TRYPTASE LEVELS; ADULT PATIENTS; RISK-FACTORS;

D O I：

10.1016/j.jaci.2015.08.034

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria for cutaneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutaneous manifestations in patients with mastocytosis. To address this unmet need, an international task force involving experts from different organizations (including the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology) met several times between 2010 and 2014 to discuss the classification and criteria for diagnosis of cutaneous manifestations in patients with mastocytosis. This article provides the major outcomes of these meetings and a proposal for a revised definition and criteria. In particular, we recommend that the typical maculopapular cutaneous lesions (urticaria pigmentosa) should be subdivided into 2 variants, namely a monomorphic variant with small maculopapular lesions, which is typically seen in adult patients, and a polymorphic variant with larger lesions of variable size and shape, which is typically seen in pediatric patients. Clinical observations suggest that the monomorphic variant, if it develops in children, often persists into adulthood, whereas the polymorphic variant may resolve around puberty. This delineationmight have important prognostic implications, and its implementation in diagnostic algorithms and future mastocytosis classifications is recommended. Refinements are also suggested for the diagnostic criteria of CM, removal of telangiectasia macularis eruptiva perstans from the current classification of CM, and removal of the adjunct solitary from the term solitary mastocytoma.

引用

页码：35 / 45

页数：11

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