Synthesis and In-vitro Activity of 4′-Modified Analogues of ddA as Potent Anti-HIV Agents

被引：3

作者：

Hong, Joon Hee ^{[2
]}

Oh, Chang Hyun ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Biomat Chem Res Ctr, Seoul 136791, South Korea

[2] Chosun Univ, Coll Pharm, Project Team BK 21, Kwangju 501759, South Korea

来源：

ARCHIV DER PHARMAZIE | 2009年 / 342卷 / 10期

关键词：

Antiviral agents; Deoxythreosyl C-Nucleoside; Ozonolysis; Phosphorylation; ISOMERIC DIDEOXYNUCLEOSIDES; 9-DEAZAADENOSINE; NUCLEOSIDES;

D O I：

10.1002/ardp.200900063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper reports the synthesis of novel 4'-hydrophobic pocket deoxythreosyl C-nucleosides. The key threose-like intermediates 9 and 14 were constructed from acyclic ketone derivatives, respectively. The antiviral activities of the synthesized compounds against the HIV-1, HSV-1, HSV-2, and HCMV viruses were evaluated. The 9-deaza-adenine derivatives 10 and 20 showed good anti-HIV activity without exhibiting significant cytotoxicity.

引用

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页码：600 / 604

页数：5

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