Isolation, Identification and Characterization of Process Related Impurity in 2-Isopropyl-4-hydroxy Anisole

被引：0
|
作者：
Thapa, M. [1 ]
Vansadiya, R. [1 ]
Nautiyal, R. [1 ]
Shah, C. C. [1 ]
Deo, Keshav [1 ]
机构：
[1] Alemb Ltd, Alemb Res Ctr, Analyt Dev Lab, Vadodara 390003, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 06期
关键词：
2-Isopropyl-4-hydroxy anisole; Impurity; HPLC; LIQUID-CHROMATOGRAPHY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One impurity in 2-isopropyl-4-hydroxy anisole at level ca. 0.2% at relative retention time ca. 2.30 is detected by reversed phase HPLC. This impurity is isolated from the enriched impurity sample using reversed phase preparative HPLC. Based on the spectral data (IR, NMR, (13)C NMR and MS) impurity is characterized as dimer of 2-isopropyl-4-hydroxy anisole.
引用
收藏
页码：4425 / 4428
页数：4
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