Nanogap Field-Effect Transistor Biosensors for Electrical Detection of Avian Influenza

被引：99

作者：

Gu, Bonsang ^{[1
]}

Park, Tae Jung ^{[2
]}

Ahn, Jae-Hyuk ^{[1
]}

Huang, Xing-Jiu ^{[1
]}

Lee, Sang Yup ^{[2
]}

Choi, Yang-Kyu ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Sch Elect Engn & Comp Sci, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea

来源：

SMALL | 2009年 / 5卷 / 21期

关键词：

avian influenza; biosensors; field-effect transistors; nanogap materials; silica-binding proteins; LABEL-FREE DETECTION; NANOWIRE DEVICES; DNA; FABRICATION; PROTEINS;

D O I：

10.1002/smll.200900450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A label-free biosensor based on a nanogap-embedded field-effect transistor is demonstrated (see image). When biomolecules fill the molecular-sized nanogap, the transistor parameters are remarkably changed by the gate dielectric constant. The transistor detects specific binding between the avian influenza antibody and an antigen with the silica-binding protein. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2407 / 2412

页数：6

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