CYTOGENETIC ABNORMALITIES IN LYMPHOCYTES EVALUATED WITH MICRONUCLEUS ASSAY IN MEDICAL PERSONNEL OCCUPATIONALLY EXPOSED TO IONIZING RADIATION

被引：2

作者：

Velickova, Nevenka ^{[1
]}

Milev, Misko ^{[1
]}

Ruskovska, Tatjana ^{[1
]}

Petrova, Biljana ^{[1
]}

Nedeljkovik, Bojana ^{[1
]}

Gorgieva, Pale ^{[1
]}

机构：

[1] Univ Goce Delcev, Fac Med Sci, Krste Misirkov 10-A, Stip 2000, Macedonia

来源：

GENETIKA-BELGRADE | 2015年 / 47卷 / 03期

关键词：

micronucleus; lymphocytes; genotoxicity; ionizing radiation; cancer; PERIPHERAL-BLOOD LYMPHOCYTES; DNA-DAMAGE; THYROID-CANCER; FREQUENCY; RISK; POPULATION; INCLUSION; APOPTOSIS; CELLS; SEX;

D O I：

10.2298/GENSR1503927V

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

The aim of this study was to evaluate the genotoxicity of ionizing radiation on medical personnel using the micronucleus assay and to determine the human health risk. Paired Student's t-test shows significant statistical difference between the total number of binucleated (BN) cells with micronuclei within the two groups (exposed and control) (t=6,812; p<0,05). The mean of MN frequencies in the exposed group increased in comparison with the mean of MN frequencies in the control group. The formation of small and large micronuclei indicates that medical personnel who are exposed on radiation in their work place, have a chromosomal instability and a risk of cancer.

引用

页码：927 / 939

页数：13

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