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- [29] Organosulfates in PM2.5[J]. PROGRESS IN CHEMISTRY, 2017, 29 (05) : 530 - 538Han, DewenWang, XintongJu, FashuaiWang, YangjunFeng, JialiangWang, Wu
Potential role of PM2.5 in melanogenesis
被引：26
|作者：
Peng, Fen
[1
]
Tsuji, Gaku
[2
,3
]
Zhang, Jian-zhong
[1
]
Chen, Zhou
[1
]
Furue, Masutaka
[2
,3
,4
]
机构：
[1] Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
[2] Kyushu Univ, Fac Med Sci, Grad Sch Med, Dept Dermatol, Fukuoka, Fukuoka 8128582, Japan
[3] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Fukuoka, Fukuoka 8128582, Japan
[4] Kyushu Univ, Fac Med Sci, Grad Sch Med, Div Skin Surface Sensing,Dept Dermatol, Fukuoka, Fukuoka 8128582, Japan
关键词：
Particulate matter 2.5;
Aryl hydrocarbon receptor;
Reactive oxygen species;
Melanogenesis;
Hyperpigmentation;
ARYL-HYDROCARBON RECEPTOR;
POLYCYCLIC AROMATIC-HYDROCARBONS;
AIRBORNE PARTICULATE MATTER;
OXIDATIVE STRESS;
EXPOSURE;
POLLUTION;
URBAN;
KERATINOCYTES;
MODULATION;
EXPRESSION;
D O I：
10.1016/j.envint.2019.105063
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ;
0830 ;
摘要：
Ambient particulate matter 2.5 (PM2.5) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect of PM2.5 on human skin and its biological significance in skin homeostasis remain incompletely understood. Previous studies demonstrated that PM2.5 can activate aryl hydrocarbon receptor (AhR), generate reactive oxygen species, and induce skin inflammation. These processes may be involved in melanocyte homeostasis and melanogenesis. We hypothesize that AhR signaling may be responsible for PM2.5-related hyperpigmentation.
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页数：4
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