A sib-pair study of psychoticism, life events and depression

被引:11
|
作者
Pickering, A [1 ]
Farmer, A [1 ]
Harris, T [1 ]
Redman, K [1 ]
Mahmood, A [1 ]
Sadler, S [1 ]
McGuffin, P [1 ]
机构
[1] Univ Wales Coll Med, Div Psychol Med, Cardiff CF14 4XN, S Glam, Wales
关键词
psychoticism; depression; life events; adversity; personality; familial;
D O I
10.1016/S0191-8869(02)00036-3
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The Psychoticism (P) scale of the Eysenck Personality Questionnaire (EPQ) (Eysenck & Eysenck, 1975) was originally proposed as a measure of the predisposition to psychotic breakdown, however, subsequent research has suggested that the P-scale is measuring a thoughtless and reckless personality. This study aims to further examine the construct of P, its relation to the experience of adversity and the development of depression. One hundred and eight depressed probands and their nearest aged siblings were compared to 105 control probands and their nearest aged siblings. All were interviewed using the Schedule for the Clinical Assessment of Neuropsychiatry (Wing, Babor, Brugha et al., 1990) and the Life Events and Difficulties Schedule (Brown & Harris, 1978). Subjects also completed the Beck Depression Inventory (BDI) (Beck, 1961) and the EPQ at the time of interview. It was found that four factors underlie the P-scale, namely Cruel/ Hostile, Anti-social, Impulsiveness, Recklessness/Fecklessness. The P-scale is familial and scores correlate positively with severe and threatening life events and BDI score at the time of interview. It is concluded that high P-scale scorers are predisposed to personality traits that are associated with an excess of severe and threatening life events, which in turn can lead to the development of depression. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:613 / 623
页数:11
相关论文
共 50 条
  • [21] Disentangling the autism phenotype; a sib-pair analysis.
    Szatmari, P
    Merette, C
    Emond, C
    Zwaigenbaum, L
    Maziade, M
    Roy, MA
    Palmour, R
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) : 391 - 391
  • [22] A new transmission test for affected sib-pair families
    Hongyan Xu
    Varghese George
    [J]. BMC Proceedings, 1 (Suppl 1)
  • [23] Mapping genes for schizophrenia with discordant sib-pair sampling
    Moldin, SO
    [J]. SCHIZOPHRENIA RESEARCH, 1997, 24 (1-2) : 56 - 57
  • [24] Autism and the X chromosome - Multipoint sib-pair analysis
    Hallmayer, J
    Hebert, JM
    Spiker, D
    Lotspeich, L
    McMahon, WM
    Petersen, PB
    Nicholas, P
    Pingree, C
    Lin, AA
    CavalliSforza, LL
    Risch, N
    Ciaranello, RD
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 1996, 53 (11) : 985 - 989
  • [25] A POWERFUL TEST OF SIB-PAIR LINKAGE FOR DISEASE SUSCEPTIBILITY
    KNAPP, M
    [J]. GENETIC EPIDEMIOLOGY, 1991, 8 (02) : 141 - 141
  • [26] Accurate inference of relationships in sib-pair linkage studies
    Boehnke, M
    Cox, NJ
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (02) : 423 - 429
  • [27] Detection of vulnerability loci by association and sib-pair methods
    Levinson, DF
    [J]. GENETIC EPIDEMIOLOGY, 1995, 12 (06) : 631 - 635
  • [28] Heritability of EEG coherence in a large sib-pair population
    Chorlian, David B.
    Tang, Yongqiang
    Rangaswamy, Madhavi
    O'Connor, Sean
    Rohrbaugh, John
    Taylor, Robert
    Porjesz, Bernice
    [J]. BIOLOGICAL PSYCHOLOGY, 2007, 75 (03) : 260 - 266
  • [29] A test statistic to detect errors in sib-pair relationships
    Ehm, MG
    Wagner, M
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (01) : 181 - 188
  • [30] A search for schizophrenia genes by affected sib-pair analysis
    Wildenauer, DB
    Schwab, SG
    Eckstein, G
    Hoenig, S
    Albus, M
    Hallmayer, J
    Borrmann, M
    Lichtermann, D
    Fimmers, R
    Ebstein, RP
    Lerer, B
    Risch, N
    Maier, W
    [J]. BIOLOGICAL PSYCHIATRY, 1996, 39 (07) : 391 - 391