Trypsin proteolytic activity in cervical cancer and precursor lesions

被引：0
|
作者：
Peregrina-Sandoval, Jorge [1 ,2 ]
del Toro-Arreola, Susana [3 ]
Oceguera-Villanueva, Antonio [2 ,6 ]
Cerda-Camacho, Felipe [2 ]
del Toro-Arreola, Alicia [4 ]
Gonzalez-Ramella, Oscar [5 ]
Jesse-Haramati [1 ]
Daneri-Navarro, Adrian [4 ]
机构：
[1] Univ Guadalajara, CUCBA, Dept Biol Celular & Mol, Lab Inmunobiol, Guadalajara, Jalisco, Mexico
[2] OPD Hosp Civil Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
[3] Univ Guadalajara, CUCS, Dept Biol Mol & Genom, Inst Enfermedades Cron Degenerat, Guadalajara, Jalisco, Mexico
[4] Univ Guadalajara, CUCS, Dept Fisiol, Lab Inmunol, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico
[5] Univ Guadalajara, CUCS, Inst Invest Cancer Infantil & Adolescencia, Guadalajara, Jalisco, Mexico
[6] Inst Jalisciense Cancerol, Guadalajara, Jalisco, Mexico
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 05期
关键词：
Trypsin; cervical cancer; serine proteases; ACTIVATED RECEPTOR-2; HUMAN-PAPILLOMAVIRUS; EXPRESSION; CARCINOMA; PROTEASE; INHIBITORS; INVASION; EXTRACTS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of the present study was to study the expression and activity of trypsin in tissues from patients with cervical cancer and precursor lesions. Immunohistochemistry assays were used to analyze trypsin expression in fixed paraffin-embedded tumor tissues obtained from patients with squamous cervical carcinomas (large-cell keratinizing and non-keratinizing types) and squamous intraepithelial lesions. Proteolytic activity was evaluated in tissue extracts by zymography. Human papillomavirus (HPV) genotyping was performed using PCR. We describe for the first time that trypsin is expressed in invasive squamous cervical carcinomas. Both trypsin expression and proteolytic activity were linked to tumor progression. Our data suggest that trypsin, directly or indirectly, plays a key role in cervical cancer progression.
引用
收藏
页码：5587 / 5593
页数：7
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