LYL797, a ROR1 CAR T-cell therapy with genetic and epigenetic reprogramming for solid tumors

被引：0

作者：

Park, Spencer ^{[1
]}

Simianer, Courtney ^{[1
]}

Spadinger, Sydney ^{[1
]}

Wang, Xiao ^{[1
]}

Sundar, Purnima ^{[1
]}

Potluri, Shobha ^{[1
]}

Lynn, Rachel ^{[1
]}

Boldajipour, Bijan ^{[1
]}

Wang, Grace ^{[1
]}

Sharma, Neeraj ^{[1
]}

Hiraragi, Hajime ^{[1
]}

Krishnamoorthy, Veena ^{[1
]}

Vodnala, Suman Kumar ^{[1
]}

Ong, E-Ching ^{[1
]}

Wu, Chang-Chih ^{[2
]}

Wohlfahrt, Martin ^{[1
]}

Ryu, Byoung ^{[2
]}

Song, Lisa ^{[3
]}

Weitzner, Brian D. ^{[3
]}

Moffett, Howell ^{[3
]}

Lajoie, Marc ^{[3
]}

Boyken, Scott ^{[3
]}

Shabaneh, Tamer ^{[4
]}

Srivastava, Shivani ^{[4
]}

Albertson, Tina ^{[1
]}

Sather, Blythe ^{[5
]}

机构：

[1] Lyell Immunopharma Inc, San Francisco, CA USA

[2] Umoja Biopharma, Seattle, WA USA

[3] Outpace Bio Inc, Seattle, WA USA

[4] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[5] Lyell Immunopharma Inc, San Francisco, CA USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2754

引用

页数：2

共 50 条

[1] Preclinical Development of LYL797, a ROR1-Targeted CAR T-Cell Therapy Enhanced with Genetic and Epigenetic Reprogramming for Solid Tumors
Park, Spencer
Wang, Xiao
Simianer, Courtney
Spadinger, Sydney
Sharma, Neeraj
Lu, Jia
Ryu, Byoung
Song, Lisa
Weitzner, Brian
Moffett, Howell
Lajoie, Marc
Boyken, Scott
Vong, Queenie
Sundar, Purnima
Vodnala, Suman
Hiraragi, Hajime
Boldajipour, Bijan
Lynn, Rachel
Potluri, Shobha
Sather, Blythe
[J]. MOLECULAR THERAPY, 2022, 30 (04) : 311 - 311
[2] Phase I study of LYL797, a ROR1-targeted CAR T-cell therapy with genetic and epigenetic reprogramming for the treatment of advanced solid tumors
Spigel, D. R.
Murthy, H.
Chumsri, S.
Ganguly, B. J.
Gong, L.
Hiraragi, H.
Larsen, E.
Liu, W.
Martell, L.
Zhu, S.
Bornman, I-M.
Fitzsimmons, S.
Barnum, E.
Christiansen, S.
Gillenwater, H.
[J]. ANNALS OF ONCOLOGY, 2022, 33 (07) : S896 - S896
[3] LYL119, an investigational ROR1-targeted CAR T-cell product incorporating four novel reprogramming technologies designed for effective cell therapy for solid tumors
Lam, Viola C.
Li, Aileen
Casas, Meritxell Galindo
Barragan, Jessica
Cheung, Christina
Briones, Jessica
Afreen, Esha
Vavra, Grant
Lu, Jia
Sundar, Purnima
Martinez, Rowena
Sims, Candace
Potluri, Shobha
Ali, Omar
Cheung, Alexander S.
Lynn, Rachel C.
[J]. CANCER RESEARCH, 2024, 84 (06)
[4] Preclinical Development of LYL119, a ROR1-Targeted CAR T-Cell Product Candidate Incorporating Four Novel T-Cell Reprogramming Technologies to Overcome Barriers to Effective Cell Therapy for Solid Tumors
Lam, Viola C.
Barragan, Jessica
Cheung, Christina
Li, Aileen
Briones, Jessica
Sundar, Purnima
Hiraragi, Hajime
Potluri, Shobha
Cheung, Alexander
Lynn, Rachel C.
[J]. MOLECULAR THERAPY, 2023, 31 (04) : 535 - 535
[5] CAR T-cell therapy of solid tumors
Yong, Carmen S. M.
Dardalhon, Valerie
Devaud, Christel
Taylor, Naomi
Darcy, Phillip K.
Kershaw, Michael H.
[J]. IMMUNOLOGY AND CELL BIOLOGY, 2017, 95 (04): : 356 - 363
[6] CAR T-cell Therapy for Solid Tumors?
Harper, Kristin
[J]. CANCER DISCOVERY, 2018, 8 (11) : 1341 - 1341
[7] CAR T-Cell Therapy in Children with Solid Tumors
Kulczycka, Marika
Derlatka, Kamila
Tasior, Justyna
Lejman, Monika
Zawitkowska, Joanna
[J]. JOURNAL OF CLINICAL MEDICINE, 2023, 12 (06)
[8] Developing ROR1 Targeting CAR-T Cells against Solid Tumors in Preclinical Studies
Lee, Boon Kiat
Wan, Yuhua
Chin, Zan Lynn
Deng, Linyan
Deng, Mo
Leung, Tze Ming
Hua, Jian
Zhang, Hua
[J]. CANCERS, 2022, 14 (15)
[9] An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors
Gohil, Satyen Harish
Paredes-Moscosso, Solange Rosa
Harrasser, Micaela
Vezzalini, Marzia
Scarpa, Aldo
Morris, Emma
Davidoff, Andrew M.
Sorio, Claudio
Nathwani, Amit Chunilal
Della Peruta, Marco
[J]. ONCOIMMUNOLOGY, 2017, 6 (07):
[10] A ROR1 SPECIFIC CD3 BISPECIFIC T-CELL ENGAGER ENGINEERED FOR SOLID TUMORS WITH AN EXPANDED THERAPEUTIC WINDOW
Rabinovich, Brian
Zhou, Xueyuan
Takimoto, Jeffrey
Song, Paul
Alici, Evren
Khanna, Nikhita
[J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1110 - A1110

← 1 2 3 4 5 →