Preclinical Development of LYL119, a ROR1-Targeted CAR T-Cell Product Candidate Incorporating Four Novel T-Cell Reprogramming Technologies to Overcome Barriers to Effective Cell Therapy for Solid Tumors

被引:0
|
作者
Lam, Viola C. [1 ]
Barragan, Jessica [1 ]
Cheung, Christina [1 ]
Li, Aileen [1 ]
Briones, Jessica [1 ]
Sundar, Purnima [1 ]
Hiraragi, Hajime [1 ]
Potluri, Shobha [1 ]
Cheung, Alexander [1 ]
Lynn, Rachel C. [1 ]
机构
[1] Lyell Immunopharma, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
1118
引用
下载
收藏
页码:535 / 535
页数:1
相关论文
共 19 条
  • [1] LYL119, an investigational ROR1-targeted CAR T-cell product incorporating four novel reprogramming technologies designed for effective cell therapy for solid tumors
    Lam, Viola C.
    Li, Aileen
    Casas, Meritxell Galindo
    Barragan, Jessica
    Cheung, Christina
    Briones, Jessica
    Afreen, Esha
    Vavra, Grant
    Lu, Jia
    Sundar, Purnima
    Martinez, Rowena
    Sims, Candace
    Potluri, Shobha
    Ali, Omar
    Cheung, Alexander S.
    Lynn, Rachel C.
    CANCER RESEARCH, 2024, 84 (06)
  • [2] Preclinical Development of LYL797, a ROR1-Targeted CAR T-Cell Therapy Enhanced with Genetic and Epigenetic Reprogramming for Solid Tumors
    Park, Spencer
    Wang, Xiao
    Simianer, Courtney
    Spadinger, Sydney
    Sharma, Neeraj
    Lu, Jia
    Ryu, Byoung
    Song, Lisa
    Weitzner, Brian
    Moffett, Howell
    Lajoie, Marc
    Boyken, Scott
    Vong, Queenie
    Sundar, Purnima
    Vodnala, Suman
    Hiraragi, Hajime
    Boldajipour, Bijan
    Lynn, Rachel
    Potluri, Shobha
    Sather, Blythe
    MOLECULAR THERAPY, 2022, 30 (04) : 311 - 311
  • [3] Phase I study of LYL797, a ROR1-targeted CAR T-cell therapy with genetic and epigenetic reprogramming for the treatment of advanced solid tumors
    Spigel, D. R.
    Murthy, H.
    Chumsri, S.
    Ganguly, B. J.
    Gong, L.
    Hiraragi, H.
    Larsen, E.
    Liu, W.
    Martell, L.
    Zhu, S.
    Bornman, I-M.
    Fitzsimmons, S.
    Barnum, E.
    Christiansen, S.
    Gillenwater, H.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S896 - S896
  • [4] LYL797, a ROR1 CAR T-cell therapy with genetic and epigenetic reprogramming for solid tumors
    Park, Spencer
    Simianer, Courtney
    Spadinger, Sydney
    Wang, Xiao
    Sundar, Purnima
    Potluri, Shobha
    Lynn, Rachel
    Boldajipour, Bijan
    Wang, Grace
    Sharma, Neeraj
    Hiraragi, Hajime
    Krishnamoorthy, Veena
    Vodnala, Suman Kumar
    Ong, E-Ching
    Wu, Chang-Chih
    Wohlfahrt, Martin
    Ryu, Byoung
    Song, Lisa
    Weitzner, Brian D.
    Moffett, Howell
    Lajoie, Marc
    Boyken, Scott
    Shabaneh, Tamer
    Srivastava, Shivani
    Albertson, Tina
    Sather, Blythe
    CANCER RESEARCH, 2022, 82 (12)
  • [5] Tumor-Targeted Radiation Therapy Helps Overcome the Solid Tumor T-Cell Infiltration Barrier and Promotes Mesothelin CAR T-Cell Therapy
    Mayor, Marissa
    Villena-Vargas, Jonathan
    De Biasi, Andreas
    Morello, Aurore
    Jones, David R.
    Sadelain, Michel
    Adusumilli, Prasad S.
    JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S228 - S228
  • [6] A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development
    Dickinson, Michael J.
    Barba, Pere
    Jaeger, Ulrich
    Shah, Nirav N.
    Blaise, Didier
    Briones, Javier
    Shune, Leyla
    Boissel, Nicolas
    Bondanza, Attilio
    Mariconti, Luisa
    Marchal, Anne-Laure
    Quinn, David S.
    Yang, Jennifer
    Price, Andrew
    Sohoni, Akash
    Treanor, Louise M.
    Orlando, Elena J.
    Mataraza, Jennifer
    Davis, Jaclyn
    Lu, Darlene
    Zhu, Xu
    Engels, Boris
    Moutouh-de Parseval, Laure
    Brogdon, Jennifer L.
    Moschetta, Michele
    Flinn, Ian W.
    CANCER DISCOVERY, 2023, 13 (09) : 1982 - 1997
  • [7] PD-1 Ligands are Upregulated after T-Cell Attack in Childhood Solid Tumors and May Become a Candidate for CAR-T Cell Therapy
    Shin, Chansu
    Kubo, Nobuhiro
    Kasahara, Yasushi
    Iwabuchi, Haruko
    Imamura, Masaru
    Saitoh, Akihiko
    Imai, Chihaya
    PEDIATRIC BLOOD & CANCER, 2018, 65 : S78 - S79
  • [8] Development of novel antigen receptors for CAR T-cell therapy directed toward solid malignancies
    Chen, David
    Yang, James
    TRANSLATIONAL RESEARCH, 2017, 187 : 11 - 21
  • [9] Preclinical development of novel humanised ROR1 targeting chimeric antigen receptor T cells and bispecific T-cell engagers
    Gohil, Satyen
    Paredes-Moscosso, Solange
    Harrasser, Micaela
    Davidoff, Andrew
    Pule, Martin
    Della Peruta, Marco
    Nathwani, Amit
    LANCET, 2017, 389 : 40 - 40
  • [10] T Cells Expressing a Modified FcgRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors
    Rasoulouniriana, Diana
    Santana-Magal, Nadine
    Gutwillig, Amit
    Farhat-Younis, Leen
    Tal, Lior
    Amar, Sarah
    Milyavsky, Michael
    Muddineni, Siva Sai Naga Anurag
    Muddineni, Anurag
    Solomon, Neta
    Shpilt, Hana
    Dotan, Shahar
    Pilpel, Noam
    Waskow, Claudia
    Feinmesser, Meora
    Rider, Peleg
    Carmi, Yaron
    CANCER IMMUNOLOGY RESEARCH, 2023, 11 (06) : 792 - 809