Pharmaceutical applications of framework nucleic acids

被引：22

作者：

Chen, Liang ^{[1
]}

Zhang, Jie ^{[1
]}

Lin, Zhun ^{[1
]}

Zhang, Ziyan ^{[1
]}

Mao, Miao ^{[1
]}

Wu, Jiacheng ^{[1
]}

Li, Qian ^{[2
,3
,4
]}

Zhang, Yuanqing ^{[1
]}

Fan, Chunhai ^{[2
,3
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Natl Ctr Translat Med, Shanghai 200240, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Key Lab Nucle Acids Chem & Nanomed, Renji Hosp, Inst Mol Med,Sch Med, Shanghai 200127, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2022年 / 12卷 / 01期

关键词：

DNA nanotechnology; Self-assembly; Framework nucleic acids; DNA nanostructures; Drug discovery; Therapeutic molecules; Drug delivery; Drug analysis; TETRAHEDRAL DNA NANOSTRUCTURE; CHAIN-REACTION AMPLIFICATION; ELECTROCHEMICAL DETECTION; ORIGAMI NANOSTRUCTURES; FOLDING DNA; DELIVERY; MEMBRANE; RNA; NANOPARTICLES; APTAMER;

D O I：

10.1016/j.apsb.2021.05.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids (FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：76 / 91

页数：16

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