Pharmaceutical applications of framework nucleic acids

被引：22

作者：

Chen, Liang ^{[1
]}

Zhang, Jie ^{[1
]}

Lin, Zhun ^{[1
]}

Zhang, Ziyan ^{[1
]}

Mao, Miao ^{[1
]}

Wu, Jiacheng ^{[1
]}

Li, Qian ^{[2
,3
,4
]}

Zhang, Yuanqing ^{[1
]}

Fan, Chunhai ^{[2
,3
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Natl Ctr Translat Med, Shanghai 200240, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Key Lab Nucle Acids Chem & Nanomed, Renji Hosp, Inst Mol Med,Sch Med, Shanghai 200127, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2022年 / 12卷 / 01期

关键词：

DNA nanotechnology; Self-assembly; Framework nucleic acids; DNA nanostructures; Drug discovery; Therapeutic molecules; Drug delivery; Drug analysis; TETRAHEDRAL DNA NANOSTRUCTURE; CHAIN-REACTION AMPLIFICATION; ELECTROCHEMICAL DETECTION; ORIGAMI NANOSTRUCTURES; FOLDING DNA; DELIVERY; MEMBRANE; RNA; NANOPARTICLES; APTAMER;

D O I：

10.1016/j.apsb.2021.05.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids (FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：76 / 91

页数：16

共 50 条

[1] Pharmaceutical applications of framework nucleic acids
Liang Chen
Jie Zhang
Zhun Lin
Ziyan Zhang
Miao Mao
Jiacheng Wu
Qian Li
Yuanqing Zhang
Chunhai Fan
[J]. Acta Pharmaceutica Sinica B, 2022, 12 (01) : 76 - 91
[2] Rational Design of Framework Nucleic Acids for Bioanalytical Applications
Su, Yuwei
Li, Dan
Liu, Bingyi
Xiao, Mingshu
Wang, Fei
Li, Li
Zhang, Xueli
Pei, Hao
[J]. CHEMPLUSCHEM, 2019, 84 (05): : 512 - 523
[3] Applications of modified nucleic acids and peptide nucleic acids
Corey, DR
[J]. METHODS, 2001, 23 (02) : 95 - 96
[4] Solidifying framework nucleic acids
Yuliang Zhao
[J]. Science China Chemistry, 2018, (12) : 1481 - 1482
[5] Solidifying framework nucleic acids
Zhao, Yuliang
[J]. SCIENCE CHINA-CHEMISTRY, 2018, 61 (12) : 1481 - 1482
[6] Solidifying framework nucleic acids
Yuliang Zhao
[J]. Science China Chemistry, 2018, 61 : 1481 - 1482
[7] Solidifying framework nucleic acids
Yuliang Zhao
[J]. Science China(Chemistry)., 2018, 61 (12) - 1482
[8] Applications of peptide nucleic acids
Nielsen, PE
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (01) : 71 - 75
[9] Nucleic Acids - Chemistry and Applications
Ganesh, Krishna N.
Krishnan, Yamuna
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (24): : 12283 - 12287
[10] Nucleic Acids - Chemistry and Applications
Ganesh, Krishna N.
Krishnan, Yamuna
[J]. ORGANIC LETTERS, 2013, 15 (24) : 6115 - 6115

← 1 2 3 4 5 →