Temozolomide resistant MGMT negative/MMR proficient cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival

被引:0
|
作者
El Touny, Lara [1 ]
Harris, Erik [1 ]
Hose, Curtis [1 ]
Connelly, John [1 ]
Vengsarkar, Diana [1 ]
Monks, Anne [1 ]
Parchment, Ralph E. [1 ]
Doroshow, James H. [2 ]
Teicher, Beverly A. [2 ]
Rapisarda, Annamaria [1 ]
机构
[1] FNLCR Leidos Biomed Res Inc, Frederick, MD USA
[2] NCI, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1158/1538-7445.AM2019-270
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
270
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells
    Wang, Hongge
    Zhang, Shan
    Song, Liyan
    Qu, Meng
    Zou, Zhihua
    ONCOGENE, 2020, 39 (14) : 2905 - 2920
  • [22] Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells
    Hongge Wang
    Shan Zhang
    Liyan Song
    Meng Qu
    Zhihua Zou
    Oncogene, 2020, 39 : 2905 - 2920
  • [23] ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
    Yazinski, Stephanie A.
    Comaills, Valentine
    Buisson, Remi
    Genois, Marie-Michelle
    Nguyen, Hai Dang
    Ho, Chu Kwen
    Kwan, Tanya Todorova
    Morris, Robert
    Lauffer, Sam
    Nussenzweig, Andre
    Ramaswamy, Sridhar
    Benes, Cyril H.
    Haber, Daniel A.
    Maheswaran, Shyamala
    Birrer, Michael J.
    Zou, Lee
    GENES & DEVELOPMENT, 2017, 31 (03) : 318 - 332
  • [24] Role Of Base Excision Repair Associated AP Nuclease Activity In The Induction Of Homologous Recombination Repair Pathway and Survival Of MM Cells Following DNA Damage
    Kumar, Subodh
    Pal, Jagannath
    Shi, Jialan
    Nanjappa, Puru
    Gkotzamanidou, Maria
    Shammas, Masood
    Munshi, Nikhil
    BLOOD, 2013, 122 (21)
  • [25] IFN-β Down-Regulates the Expression of DNA Repair Gene MGMT and Sensitizes Resistant Glioma Cells to Temozolomide (vol 65, pg 7573, 2005)
    Natsume, A.
    Ishii, D.
    Wakabayashi, T.
    Tsuno, T.
    Hatano, H.
    Mizuno, M.
    CANCER RESEARCH, 2016, 76 (24) : 7293 - 7293
  • [26] Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
    Lei Liu
    Yuanyuan Chen
    Yijuan Huang
    Kun Cao
    Tingting Liu
    Hui Shen
    Jianguo Cui
    Bailong Li
    Jianming Cai
    Fu Gao
    Yanyong Yang
    Molecular Cancer, 20
  • [27] ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
    Chen, Yuanyuan
    Shen, Hui
    Liu, Tingting
    Cao, Kun
    Wan, Zhijie
    Du, Zhipeng
    Wang, Hang
    Yu, Yue
    Ma, Shengzhe
    Lu, Edward
    Zhang, Wei
    Cai, Jianming
    Gao, Fu
    Yang, Yanyong
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023, 42 (01)
  • [28] Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
    Liu, Lei
    Chen, Yuanyuan
    Huang, Yijuan
    Cao, Kun
    Liu, Tingting
    Shen, Hui
    Cui, Jianguo
    Li, Bailong
    Cai, Jianming
    Gao, Fu
    Yang, Yanyong
    MOLECULAR CANCER, 2021, 20 (01)
  • [29] ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
    Yuanyuan Chen
    Hui Shen
    Tingting Liu
    Kun Cao
    Zhijie Wan
    Zhipeng Du
    Hang Wang
    Yue Yu
    Shengzhe Ma
    Edward Lu
    Wei Zhang
    Jianming Cai
    Fu Gao
    Yanyong Yang
    Journal of Experimental & Clinical Cancer Research, 42
  • [30] "BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination" [DNA Repair 115 (2022) 103331]
    Parker, Christopher
    Chambers, Adam C.
    Flanagan, Dustin J.
    Ho, Jasmine Wing Yu
    Collard, Tracey J.
    Ngo, Greg
    Baird, Duncan M.
    Timms, Penny
    Morgan, Rhys G.
    Sansom, Owen J.
    Williams, Ann C.
    DNA REPAIR, 2025, 145