Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients

被引：7
|
作者：
Lee, H. S. [1 ,2 ]
Park, C. [1 ,2 ]
Kim, S. W. [1 ,2 ]
Song, J. W. [1 ,2 ]
Chun, B. K. [3 ]
Park, T. J.
Hong, J. C. [4 ]
Lee, K. D. [1 ,2 ]
机构：
[1] Kosin Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Busan, South Korea
[2] Kosin Univ, Coll Med, Dept Pathol, Busan, South Korea
[3] Maryknoll Med Ctr, Dept Otolaryngol Head & Neck Surg, Maryknoll, NY USA
[4] Dong A Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Busan, South Korea
来源：
JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2016年 / 130卷 / 03期
关键词：
Thyroid Neoplasms; Lymph Nodes; Lymphatic Metastasis; Pathology; EXTRANODAL EXTENSION; PROGNOSTIC-SIGNIFICANCE; EXTRACAPSULAR INVASION; POOR-PROGNOSIS; CANCER; RECURRENCE; DISEASE; NUMBER; MICROCARCINOMA; DISSECTION;
D O I：
10.1017/S0022215115003382
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective: This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients. Method: A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted. Results: A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733). Conclusion: Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.
引用
收藏
页码：302 / 308
页数：7
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