Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients

被引：7

作者：

Lee, H. S. ^{[1
,2
]}

Park, C. ^{[1
,2
]}

Kim, S. W. ^{[1
,2
]}

Song, J. W. ^{[1
,2
]}

Chun, B. K. ^{[3
]}

Park, T. J.

Hong, J. C. ^{[4
]}

Lee, K. D. ^{[1
,2
]}

机构：

[1] Kosin Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Busan, South Korea

[2] Kosin Univ, Coll Med, Dept Pathol, Busan, South Korea

[3] Maryknoll Med Ctr, Dept Otolaryngol Head & Neck Surg, Maryknoll, NY USA

[4] Dong A Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Busan, South Korea

来源：

JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2016年 / 130卷 / 03期

关键词：

Thyroid Neoplasms; Lymph Nodes; Lymphatic Metastasis; Pathology; EXTRANODAL EXTENSION; PROGNOSTIC-SIGNIFICANCE; EXTRACAPSULAR INVASION; POOR-PROGNOSIS; CANCER; RECURRENCE; DISEASE; NUMBER; MICROCARCINOMA; DISSECTION;

D O I：

10.1017/S0022215115003382

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients. Method: A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted. Results: A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733). Conclusion: Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.

引用

页码：302 / 308

页数：7

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