Parkinson's Disease: A Thalamostriatal Rebalancing Act?

被引：6
|
作者：
Tritsch, Nicolas X. [1 ]
Carter, Adam G. [2 ]
机构：
[1] NYU, Langone Med Ctr, Neurosci Inst,Dept Neurosci & Physiol, Fresco Inst Parkinsons & Movement Disorders, New York, NY 10016 USA
[2] NYU, Ctr Neural Sci, New York, NY 10003 USA
来源：
NEURON | 2016年 / 89卷 / 04期
关键词：
STRIATAL PROJECTION NEURONS; GANGLIA; SYNAPSES;
D O I：
10.1016/j.neuron.2016.02.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.
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页码：675 / 677
页数：4
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