Study of the participation of Lipoprotein Lipase gene polymorphism in coronary artery disease

The study designed to assess the association of Lipoprotein Lipase gene polymorphism with CAD. The study consists of two groups, the first group includes 93 patients with CAD and the second group includes 81 subjects with no sign, no symptom and no history of CAD. Genotyping of LPL gene polymorphism [HindIII T <-> G (SNP)] was done by PCR-RFLP. The results of present study revealed study show that TT and TG genotypes of LPL gene polymorphism [HindIII T <-> G (SNP)] was found to be non-significantly increase the risk of CAD with respect to those of the GG genotypes of LPL gene polymorphism [HindIII T <-> G (SNP)] respectively. Moreover, the outcomes of the study show that a significant increase of serum triglycerides concentration in the TT genotype of LPL gene polymorphism [HindIII T <-> G (SNP)] when compared with GG genotype of LPL gene polymorphism [HindIII T <-> G (SNP)] in patients with CAD. This study conclude that the LPL gene polymorphism [HindIII T <-> G (SNP)] was not associated with CAD and the TT genotype of LPL gene polymorphism [HindIII T <-> G (SNP)] associated with increase triglycerides in patients with CAD.