Synthesis of some novel 1-aminomethyl-3-benzoylhydrazono-2-indolinones as potential antiinflammatory agents

被引：0
|
作者：
Nagarapu, L [1 ]
Ravirala, N [1 ]
Akkewar, DM [1 ]
机构：
[1] Indian Inst Chem Technol, Div Ind Organ Chem 2, Hyderabad 500007, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 12期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Acid-catalysed condensation of hydrazides 3, obtained from substituted phenoxybenzoic acids 1 with indolin-2,3-dione 4, results into hydrazono-2-indolinones 5. Compounds 5 when subjected to Mannich reaction with different cyclic secondary amines yield 1-aminomethyl-3-benzoylhydrazono-2-indolinones 6 (Mannich bases). All these compounds (6a-i) exhibit significant antiinflammatory activity.
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页码：1254 / 1257
页数：4
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