MEDI 370-Design, synthesis and biological activity of a novel series of naphthyridinone derivatives as potent p38α MAP kinase inhibitors for the treatment of rheumatoid arthritis

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作者
Yang, Ginger XuQiang [1 ]
Stelmach, John [1 ]
Hu, Zao [1 ]
Koyama, HIroo [1 ]
Desai, Ranjit C. [1 ]
Chen, Meng-Hsin [1 ]
Natarajan, Swaminathan [1 ]
Miller, Daniel J. [1 ]
O'Keefe, Stephen [2 ]
Edward, O'neill [2 ]
Mitra, Kaushik [3 ]
Visco, Denise [4 ]
Owens, Karen [1 ]
Zaller, Dennis M. [2 ]
Doherty, Jim B. [1 ]
Sahoo, Soumya P. [1 ]
机构
[1] Merck & Co Inc, Dept Med Chem, Merck Res Labs, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
[3] Merck Res Labs, Dept Drug Metab, Rahway, NJ 07065 USA
[4] Merck Res Labs, Dept Lab Anim Resources, Rahway, NJ 07065 USA
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
370-MEDI
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页数:1
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