Long-range surface plasmon waveguide biosensors for disease detection

被引：0
|
作者：
Krupin, Oleksiy [1 ,2 ]
Wong, Wei Ru [3 ]
Berini, Pierre [1 ,2 ,4 ]
机构：
[1] Univ Ottawa, Sch Elect Engn & Comp Sci, Ottawa, ON, Canada
[2] Univ Ottawa, Ctr Res Photon, Ottawa, ON, Canada
[3] Univ Malaya, Dept Elect Engn, Kuala Lumpur 50603, Malaysia
[4] Univ Ottawa, Dept Phys, Ottawa, ON, Canada
来源：
FRONTIERS IN BIOLOGICAL DETECTION: FROM NANOSENSORS TO SYSTEMS XI | 2019年 / 10895卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
optical biosensor; long-range surface plasmon-polariton; leukemia; dengue; HIV; RESONANCE SENSORS; LIGHT-CHAINS; PROTEIN-G; SERUM; ANTIBODY; BLOOD; ASSAY; IMMOBILIZATION; INTERFEROMETER; SENSITIVITY;
D O I：
10.1117/12.2513773
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We review long-range surface plasmon-polariton waveguide biosensors and their application to disease detection in complex fluids. The biosensors are constructed from metal stripe waveguides cladded in Cytop with etched microfluidic channels to expose the stripe surface to the sensing fluid. Application of waveguide biosensors to the detection of leukemia in patient blood serum and dengue infection in patient blood plasma is reviewed. In addition, a novel bioassay for HIV detection in complex fluids is proposed and preliminary results are demonstrated. The biosensors are compact and mass manufacturable using semiconductor fabrication tools and processes.
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页数：11
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