Culture development for human embryonic stem cell propagation: molecular aspects and challenges

被引：50
|
作者：
Rao, BM [1 ]
Zandstra, PW [1 ]
机构：
[1] Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2005年 / 16卷 / 05期
关键词：
D O I：
10.1016/j.copbio.2005.08.001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Basic fibroblast growth factor and members of the transforming growth factor-beta superfamily are important regulators of human embryonic stem cell (hESC) self-renewal. Extensive cross-talk between the intracellular signaling pathways activated by these factors contributes to maintenance of the undifferentiated hESC state. Understanding the molecular regulation of hESC self-renewal will facilitate the design of improved systems for hESC propagation and provide a foundation for strategies to direct the differentiation of hESCs to clinically relevant cell types.
引用
收藏
页码：568 / 576
页数：9
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