Ultraviolet irradiation-induced inhibition of histone deacetylase 4 increases the expression of matrix metalloproteinase-1 but decreases that of type I procollagen via activating JNK in human dermal fibroblasts

被引:9
|
作者
Lee, Yuri [1 ,2 ,3 ]
Shin, Mi Hee [1 ,3 ]
Kim, Min-Kyoung [1 ,3 ]
Park, Chi-Hyun [1 ,3 ]
Shin, Hye Sun [1 ,2 ,3 ]
Lee, Dong Hun [1 ,3 ]
Chung, Jin Ho [1 ,2 ,3 ,4 ]
机构
[1] Seoul Natl Univ, Dept Dermatol, Coll Med, Seoul, South Korea
[2] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea
[3] Seoul Natl Univ, Med Res Ctr, Inst Human Environm Interface Biol, Seoul, South Korea
[4] Seoul Natl Univ, Inst Aging, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
Histone deacetylase; Ultraviolet; Matrix metalloproteinase; Type I procollagen; Human dermal fibroblast; c-Jun N-terminal kinase;
D O I
10.1016/j.jdermsci.2020.11.008
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Ultraviolet (UV) irradiation is the main contributing factor for skin aging. UV irradiation induces epigenetic changes in skin. It increases the activity of histone acetylases (HATs) but decreases that of histone deacetylases (HDACs). Objective: We aimed to investigate alterations in all classes of HDACs and sirtuins (SIRTs) in response to UV irradiation, and determine the HDACs regulating the expressions of matrix metalloproteinase 1 (MMP-1) and type I procollagen. Methods: Primary human dermal fibroblasts were UV irradiated. HDAC4 was knocked-down or overexpressed to investigate its effect on the expression of MMP-1 and type I procollagen. The mRNA and protein levels were analyzed by quantitative real-time polymerase chain reaction and western blotting. Results: Among 11 HDACs and 7 SIRTs, we found that the expression of HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC11, SIRT2, and SIRT3 were significantly and consistently reduced by UV at both mRNA and protein levels. Among these, the reduction of HDAC4 was responsible for the basal and UV-induced increase in the expression of MMP-1 and decrease in that of type I procollagen. Furthermore, the reduced HDAC4 could activate c-Jun N-terminal kinase (JNK), resulting in an increase in MMP-1 and decrease in type I procollagen. Conclusions: UV treatment decreases the expression of HDACs and SIRTs in dermal fibroblasts; in particular, the UV-induced reduction in the expression of HDAC4 might play an important role in regulating the expression of MMP-1 and type I procollagen. (C) 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:107 / 114
页数:8
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