Measurement of dopamine receptor-mediated jaw movements by a magnet-sensing system in freely moving rats

被引:11
|
作者
Lee, J
Adachi, K
Gionhaku, N
Fujita, S
Uchida, T
Koshikawa, N
机构
[1] Nihon Univ, Sch Dent, Dept Pharmacol, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
[2] Nihon Univ, Sch Dent, Dept Complete Denture Prosthodont, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
[3] Nihon Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
[4] Nihon Univ, Sch Dent, Dept Dent Anesthesiol, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
[5] Nihon Univ, Sch Dent, Div Oral & Craniomaxillofacial Res, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
关键词
apomorphine; jaw movements; magnet-sensing system; quinpirole; SKF; 38393;
D O I
10.1358/mf.2003.25.7.778091
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study tested a system for monitoring jaw movements in freely moving rats. A Hall-effect transducer was fixed to the skull in order to sense voltage changes induced by variations in the position of a magnet fixed to the mandible. By measuring dopamine receptor-mediated jaw movements, this si,stem produces elata comparable to that obtained using it light-sensitive transducer system in anesthetized rats, while also measuring the vertical component of jaw movements in freely moving rats. In combination with conventional visual observation, this system may provide a useful tool for assessing movements of the orofacial region during spontaneous and drug-evoked behavior. (C) 2003 Prous Science. All rights reserved.
引用
收藏
页码:525 / 530
页数:6
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