A rhodium-catalysed conjugate addition/cyclization cascade for the asymmetric synthesis of 2-amino-4H-chromenes

被引：8

作者：

Chang, Zhiqian ^{[1
]}

Zhu, Huilong ^{[1
]}

Wu, Changhui ^{[1
]}

Xing, Junhao ^{[1
]}

Dou, Xiaowei ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Sci, Dept Chem, Nanjing 211198, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

36;

D O I：

10.1039/d0ob02404j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective synthesis of 2-amino-4H-chromenes via the cascade rhodium-catalysed conjugate addition/hetero Thorpe-Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodological deficiency in the asymmetric synthesis of 4-aryl 2-amino-4H-chromenes.

引用

页码：785 / 788

页数：4

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