Human embryonic stem cells: From the human embryo transgressed to the regenerative medicine of tomorrow

被引：4
|
作者：
De Vos, J. [1 ,2 ,3 ]
Assou, S. [1 ,2 ,3 ,4 ]
Tondeur, S. [1 ,2 ,3 ]
Dijon, M. [1 ,2 ]
Hamamah, S. [1 ,2 ,3 ,5 ]
机构：
[1] CHU Montpellier, Hop St Eloi, Inst Res Biotherapy, F-34000 Montpellier, France
[2] INSERM, U847, F-34000 Montpellier, France
[3] Univ Montpellier I, UFR Med, F-34000 Montpellier, France
[4] MacoPharma, F-59200 Tourcoing, France
[5] CHU Montpellier, Hop Arnaud de Villeneuve, Unite Biol Clin AMP DPI, F-34000 Montpellier, France
来源：
GYNECOLOGIE OBSTETRIQUE & FERTILITE | 2009年 / 37卷 / 7-8期
关键词：
Embryonic stem cells; Pluripotency; Human embryo; Microarrays; TRANSCRIPTIONAL REGULATORY CIRCUITRY; TRANSPLANTATION; FIBROBLASTS; BLASTOCYSTS; DERIVATION; NEURONS; CULTURE; GENES; LINES; OCT4;
D O I：
10.1016/j.gyobfe.2009.05.009
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Human embryonic stem cells (hESC) are derived front the inner cell mass (ICM) of the human blastocyst at day 5 or 6 of the early embryo development. These cells display two cardinal features: they are able to differentiate into cell types from many if not all human tissue (pluripotency) and they proliferate strongly and indefinitely without senescence in vitro. Therefore, hESC are a source of choice for stem cells for regenerative medicine and are a reference model to study the biology of pluripotency. Since 2004, the French law (loi de Bioethique) authorizes hESC research under certain conditions. (C) 2009 Published by Elsevier Masson SAS.
引用
收藏
页码：620 / 626
页数：7
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