Trifluoromethylation of flavonoids and anti-tumor activity of the trifluoromethylated flavonoid derivatives

被引：42
|
作者：
Wang, CL
Li, HQ
Meng, WD
Qing, FL
机构：
[1] Donghua Univ, Inst Biol Sci & Biotechnol, Shanghai 200051, Peoples R China
[2] Acad Sinica, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 20期
基金：
中国国家自然科学基金;
关键词：
flavonoids; trifluoromethylation;
D O I：
10.1016/j.bmcl.2005.07.047
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
3-Trifluoromethylflavonoid derivatives were prepared for the first time by trifluoromethylation of 3-iodoflavonoid derivatives. Other C ring and B ring trifluoromethylated flavonoid derivatives were also prepared. All the compounds were tested for their effect on the U2OS cell cycle in vitro. Bistrifluoromethylated apigenin derivative 13 showed the strongest activity against the cell growth. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4456 / 4458
页数：3
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