Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

被引：10
|
作者：
Agafonova, Irina G. [1 ]
Moskovkina, Taisiya V. [2 ]
机构：
[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia
[2] Far East Fed Univ, Vladivostok 690000, Russia
来源：
APPLIED MAGNETIC RESONANCE | 2015年 / 46卷 / 07期
关键词：
ISATIS-TINCTORIA; COUROUPITA-GUIANENSIS; POLYGONUM-TINCTORIUM; INDOLIC CONSTITUENTS; DERIVATIVES; INDIRUBIN; PRINCIPLE; GLYCOSIDE; PRODUCTS; AUBL;
D O I：
10.1007/s00723-015-0674-3
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.
引用
收藏
页码：781 / 791
页数：11
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