Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

被引：10

作者：

Agafonova, Irina G. ^{[1
]}

Moskovkina, Taisiya V. ^{[2
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[2] Far East Fed Univ, Vladivostok 690000, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2015年 / 46卷 / 07期

关键词：

ISATIS-TINCTORIA; COUROUPITA-GUIANENSIS; POLYGONUM-TINCTORIUM; INDOLIC CONSTITUENTS; DERIVATIVES; INDIRUBIN; PRINCIPLE; GLYCOSIDE; PRODUCTS; AUBL;

D O I：

10.1007/s00723-015-0674-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.

引用

页码：781 / 791

页数：11

共 50 条

[1] Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging
Irina G. Agafonova
Taisiya V. Moskovkina
Applied Magnetic Resonance, 2015, 46 : 781 - 791
[2] Anti-inflammatory Activity of Mollugin on DSS-induced Colitis in Mice
Juan Li
Jin-ling Zhang
Xue-peng Gong
Meng Xiao
Yuan-yuan Song
Hui-fang Pi
Guang Du
Current Medical Science, 2020, 40 : 910 - 916
[3] Anti-inflammatory Activity of Mollugin on DSS-induced Colitis in Mice
Li, Juan
Zhang, Jin-ling
Gong, Xue-peng
Xiao, Meng
Song, Yuan-yuan
Pi, Hui-fang
Du, Guang
CURRENT MEDICAL SCIENCE, 2020, 40 (05) : 910 - 916
[4] Anti-inflammatory effects of Cheongilppong on DSS-induced ulcerative colitis in mice
Choi, In-Young
Lee, Ki-Taeg
Kim, Min-Cheol
Kim, Su-Jin
Kim, Dae-Seung
Jeon, Yong-Deok
Park, Yun-Jum
Kim, Ho Soo
Lee, Dal Won
Um, Jae-Young
Hong, Seung-Neon
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE, 2011, 11 (01): : 35 - 39
[5] Anti-inflammatory effects of Cheongilppong on DSS-induced ulcerative colitis in mice
In-Young Choi
Ki-Taeg Lee
Min-Cheol Kim
Su-Jin Kim
Dae-Seung Kim
Yong-Deok Jeon
Yun-Jum Park
Ho Soo Kim
Dal Won Lee
Jae-Young Um
Seung-Heon Hong
Oriental Pharmacy & Experimental Medicine, 2011, 11 (1): : 35 - 39
[6] ANTI-INFLAMMATORY EFFECT OF FAECALIBACTERIUM PRAUSNITZII ON DSS-INDUCED COLITIS IN MICE
Wang, Jingjing
Zhu, Qihui
Ji, Guozhong
Cui, Bota
Liu, Xingyin
GASTROENTEROLOGY, 2020, 158 (06) : S1049 - S1050
[7] Anti-inflammatory activity of naringin and the biosynthesized naringenin in a model of DSS-induced colitis in mice
Amaro, Maria Ines
Rocha, Joao
Sepodes, Bruno
Mota-Filipe, Helder
Ribeiro, Maria H.
JOURNAL OF BIOTECHNOLOGY, 2008, 136 : S373 - S373
[8] The Possible Anti-Inflammatory Effect of Dehydrocostus Lactone on DSS-Induced Colitis in Mice
Zhou, Qing
Zhang, Wei-xin
He, Zong-qi
Wu, Ben-sheng
Shen, Zhao-feng
Shang, Hong-tao
Chen, Tuo
Wang, Qiong
Chen, Yu-gen
Han, Shu-tang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
[9] Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice
Benight, Nancy M.
Stoll, Barbara
Marini, Juan C.
Burrin, Douglas G.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (01): : G71 - G82
[10] Anti-inflammatory and anti-oxidant properties of Melianodiol on DSS-induced ulcerative colitis in mice
Shen, Jinhuang
Ma, Xinhua
He, Yubin
Wang, Yanjun
Zhong, Tianhua
Zhang, Yonghong
PEERJ, 2022, 10

← 1 2 3 4 5 →