Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

被引：13
|
作者：
Cheng, Aristine [1 ,2 ,3 ]
Holland, Steven M. [1 ]
机构：
[1] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
[2] Natl Taiwan Univ Hosp, Dept Med, Div Infect Dis, Taipei, Taiwan
[3] Natl Taiwan Univ, Coll Med, Taipei, Taiwan
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2022年 / 149卷 / 01期
关键词：
Anticytokine autoantibodies; anti-IFN-g; anti-IFN-alpha; anti-IL-23; anti-IL-12; anti-IL-17; anti-CM-CSF; opportu-nistic infections; adult-onset immunodeficiency; protein alveolar proteinosis; chronic mucocutaneous candidiasis; PULMONARY ALVEOLAR PROTEINOSIS; ANTI-CYTOKINE AUTOANTIBODIES; COLONY-STIMULATING FACTOR; ANTIINTERFERON-GAMMA AUTOANTIBODIES; CHRONIC MUCOCUTANEOUS CANDIDIASIS; MYCOBACTERIUM-AVIUM COMPLEX; INTERFERON-GAMMA; RITUXIMAB THERAPY; INFECTION; ANTIBODIES;
D O I：
10.1016/j.jaci.2021.11.016
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes. (J Allergy Clin Immunol 2022;149:24-8.)
引用
收藏
页码：24 / 28
页数：5
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