Anxiety and risk of dementia: Systematic review and meta-analysis of prospective cohort studies

被引：32
|
作者：
Santabarbara, Javier [1 ,2 ,3 ]
Lipnicki, Darren M. [4 ]
Villagrasa, Beatriz [5 ]
Lobo, Elena [1 ,2 ,3 ]
Lopez-Anton, Raul [2 ,3 ,6 ]
机构：
[1] Univ Zaragoza, Dept Med Prevent & Salud Publ, C Domingo Miral S-N, E-50009 Zaragoza, Spain
[2] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
[3] Ctr Invest Biomed Red Salud Mental CIBERSAM, Minist Sci & Innovat, Madrid, Spain
[4] Univ New South Wales Med, Sch Psychiat, Ctr Hlth Brain Ageing, Randwick, NSW, Australia
[5] Hosp Clin Univ, Serv Psiquiatria, Avda San Juan Bosco 15, Zaragoza 50009, Spain
[6] Univ Zaragoza, Dept Psicol & Sociol, C Doctor Cerrada 1-5, E-50009 Zaragoza, Spain
来源：
MATURITAS | 2019年 / 119卷
关键词：
Meta-analysis; Dementia; Anxiety; Risk factor; Older people; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; SYMPTOMS; DECLINE; BENZODIAZEPINE; HETEROGENEITY; INFLAMMATION; DEPRESSION;
D O I：
10.1016/j.maturitas.2018.10.014
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objectives: Anxiety is postulated to be modifiable risk factor for dementia. Our primary aim was to conduct a meta-analysis of community-based cohort studies that investigated the association between anxiety and dementia. Design: We identified relevant, high-quality papers published up to January 2018 by searching PubMed and Web of Science. Prospective cohort studies reporting relative risks (RRs) for the association between anxiety and dementia, adjusted at least for age, were considered eligible. Study-specific RRs were combined using a random-effects model. Results: Six prospective cohorts (reported in 5 studies), with a total of 10,394 participants, were included in the meta-analysis. The pooled RR of 1.29 (95% CI: 1.01-1.66) indicated a significant association between anxiety and dementia. Conclusion: Anxiety significantly increases the risk of dementia. However, further research is needed to determine the extent to which anxiety is a cause of dementia rather than a prodrome or marker.
引用
收藏
页码：14 / 20
页数：7
相关论文
共 50 条
  • [31] Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies
    Santabarbara, Javier
    Lipnicki, Darren M.
    Olaya, Beatriz
    Villagrasa, Beatriz
    Bueno-Notivol, Juan
    Nuez, Lucia
    Lopez-Anton, Raul
    Gracia-Garcia, Patricia
    [J]. JOURNAL OF CLINICAL MEDICINE, 2020, 9 (06) : 1 - 13
  • [32] Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies
    Jiang, Ning
    Ma, Jinlong
    Wang, Qian
    Xu, Yuzhen
    Wei, Baojian
    [J]. PEERJ, 2023, 11
  • [33] Association of statin use with risk of dementia: A meta-analysis of prospective cohort studies
    Song, Yu
    Nie, Hongwei
    Xu, Yong
    Zhang, Ling
    Wu, Yan
    [J]. GERIATRICS & GERONTOLOGY INTERNATIONAL, 2013, 13 (04) : 817 - 824
  • [34] Dietary Patterns and Risk of Stroke in Adults: A Systematic Review and Meta-analysis of Prospective Cohort Studies
    Zhang, Xiaoyan
    Shu, Long
    Si, Caijuan
    Yu, Xiaolong
    Gao, Wei
    Liao, Dan
    Zhang, Lun
    Liu, Xiaoli
    Zheng, Peifen
    [J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2015, 24 (10): : 2173 - 2182
  • [35] Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies
    Kunutsor, Setor K.
    Makikallio, Timo H.
    Seidu, Samuel
    Soares de Araujo, Claudio Gil
    Dey, Richard S.
    Blom, Ashley W.
    Laukkanen, Jari A.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2020, 35 (05) : 431 - 442
  • [36] Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies
    Jamnik, Joseph
    Rehman, Sara
    Mejia, Sonia Blanco
    de Souza, Russell J.
    Khan, Tauseef A.
    Leiter, Lawrence A.
    Wolever, Thomas M. S.
    Kendall, Cyril W. C.
    Jenkins, David J. A.
    Sievenpiper, John L.
    [J]. BMJ OPEN, 2016, 6 (10):
  • [37] Marriage and risk of dementia: systematic review and meta-analysis of observational studies
    Sommerlad, Andrew
    Ruegger, Joshua
    Singh-Manoux, Archana
    Lewis, Glyn
    Livingston, Gill
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 (03): : 231 - 238
  • [38] Coffee consumption and risk of colorectal cancer: A systematic review and meta-analysis of prospective cohort studies
    Je, Youjin
    Liu, Wei
    Giovannucci, Edward
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (07) : 1662 - 1668
  • [39] Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies
    Setor K. Kunutsor
    Timo H. Mäkikallio
    Samuel Seidu
    Claudio Gil Soares de Araújo
    Richard S. Dey
    Ashley W. Blom
    Jari A. Laukkanen
    [J]. European Journal of Epidemiology, 2020, 35 : 431 - 442
  • [40] Proton pump inhibitors do not increase the risk of dementia: a systematic review and meta-analysis of prospective studies
    Desai, Madhav
    Nutalapati, Venkat
    Srinivasan, Sachin
    Fathallah, Jihan
    Dasari, Chandra
    Chandrasekhar, Viveksandeep Thoguluva
    Mohammad, Bilal
    Kohli, Divyanshoo
    Vaezi, Michael
    Katz, Philip O.
    Sharma, Prateek
    [J]. DISEASES OF THE ESOPHAGUS, 2020, 33 (10)
12345