Synthesis of New Pyridazine Derivatives as Potential Anti-HIV-1 Agents

被引：4

作者：

Ferro, Stefania ^{[1
]}

Agnello, Stefano ^{[1
]}

Barreca, Maria Letizia ^{[2
]}

De Luca, Laura ^{[1
]}

Christ, Frauke ^{[3
,4
]}

Gitto, Rosaria ^{[1
]}

机构：

[1] Univ Messina, Dept Med Chem, I-98168 Messina, Italy

[2] Univ Perugia, Dept Pharmaceut Chem & Technol, I-06123 Perugia, Italy

[3] Katholieke Univ Leuven, B-3000 Louvain, Belgium

[4] IRC KULAK, B-3000 Louvain, Belgium

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 06期

关键词：

HIV-1 INTEGRASE INHIBITORS; STRAND-TRANSFER INHIBITORS;

D O I：

10.1002/jhet.230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report conventional and microwave-assisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIV-1 integrase (IN) enzyme inhibition activity. The biological screening highlighted that only derivative 5 proved to be a strand-transfer step inhibitor of the virus integration process at micromolar concentration.

引用

下载

页码：1420 / 1424

页数：5

共 50 条

[1] Synthesis of some novel substituted purine derivatives as potential anticancer, anti-HIV-1 and antimicrobial agents
Rida, Samia M.
Ashour, Fawzia A.
El-Hawash, Soad A. M.
El-Semary, Mona M.
Badr, Mona H.
ARCHIV DER PHARMAZIE, 2007, 340 (04) : 185 - 194
[2] RIBOZYMES AS POTENTIAL ANTI-HIV-1 THERAPEUTIC AGENTS
SARVER, N
CANTIN, EM
CHANG, PS
ZAIA, JA
LADNE, PA
STEPHENS, DA
ROSSI, JJ
SCIENCE, 1990, 247 (4947) : 1222 - 1225
[3] Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents
Safakish, Mahdieh
Hajimahdi, Zahra
Zabihollahi, Rezvan
Aghasadeghi, Mohammad R.
Vahabpour, Rouhoullah
Zarghi, Afshin
MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (11) : 2718 - 2726
[4] Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents
Mahdieh Safakish
Zahra Hajimahdi
Rezvan Zabihollahi
Mohammad R. Aghasadeghi
Rouhoullah Vahabpour
Afshin Zarghi
Medicinal Chemistry Research, 2017, 26 : 2718 - 2726
[5] Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents
Zhang, Lingzi
Guo, Jian
Liu, Xin
Liu, Huiqing
De Clercq, Erik
Pannecouque, Christophe
Liu, Xinyong
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (03) : 333 - 343
[6] Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents
Dong, Ming-xin
Zhang, Jian
Peng, Xu-qing
Lu, Hong
Yun, Liu-hong
Jiang, Shibo
Dai, Qiu-yun
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) : 4096 - 4103
[7] Synthesis of some novel benzoxazole derivatives as anticancer, anti-HIV-1 and antimicrobial agents
Rida, SM
Ashour, FA
El-Hawash, SAM
Elsemary, MM
Badr, MH
Shalaby, MA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (09) : 949 - 959
[8] Synthesis andin vitro evaluation of some novel benzofuran derivatives as potential anti-HIV-1, anticancer, and antimicrobial agents
Samia M. Rida
Soad A. M. El-Hawash
Hesham T. Y. Fahmy
Aly A. Hazza
Mostafa M. M. El-Meligy
Archives of Pharmacal Research, 2006, 29
[9] SYNTHESIS OF THYMIDINE DERIVATIVES 3'-MODIFIED WITH A POLAR 3-ATOM GROUP AS POTENTIAL ANTI-HIV-1 AGENTS
HIROTA, K
HOSONO, H
KITADE, Y
MAKI, Y
CHU, CK
SCHINAZI, RF
MURAOKA, O
NUCLEOSIDES & NUCLEOTIDES, 1992, 11 (10): : 1731 - 1738
[10] Synthesis and evaluation of pyridinium polyoxometalates as anti-HIV-1 agents
Wang, Shunyi
Sun, Wuji
Hu, Qin
Yan, Hong
Zeng, Yi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (11) : 2357 - 2359

← 1 2 3 4 5 →