Chromosome Instability Drives Tumor Evolution

被引：2
|
作者：
Dolgin, Elie
机构：
来源：
CANCER DISCOVERY | 2017年 / 7卷 / 06期
关键词：
D O I：
10.1158/2159-8290.CD-ND2017-003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A prospective study of patients with non-small cell lung cancer undergoing treatment reveals that chromosomal instability and tumor heterogeneity drive disease recurrence. Researchers involved in the TRACERx trial documented that genetic diversity by sequencing multiple regions of the primary tumor and then created bespoke ctDNA tests that allowed for early detection of relapse and metastasis. ©2017 American Association for Cancer Research.
引用
收藏
页码：546 / 546
页数：1
相关论文
共 50 条
  • [21] Chromosomal instability and marker chromosome evolution in oral squamous cell carcinoma
    Reshmi, SC
    Saunders, WS
    Kudla, DM
    Ragin, CR
    Gollin, SM
    GENES CHROMOSOMES & CANCER, 2004, 41 (01): : 38 - 46
  • [22] Sex-Specific Adaptation Drives Early Sex Chromosome Evolution in Drosophila
    Zhou, Qi
    Bachtrog, Doris
    SCIENCE, 2012, 337 (6092) : 341 - 345
  • [23] Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
    Delaney, Joe R.
    Patel, Chandni B.
    Bapat, Jaidev
    Jones, Christian M.
    Ramos-Zapatero, Maria
    Ortell, Katherine K.
    Tanios, Ralph
    Haghighiabyaneh, Mina
    Axelrod, Joshua
    DeStefano, John W.
    Tancioni, Isabelle
    Schlaepfer, David D.
    Harismendy, Olivier
    La Spada, Albert R.
    Stupack, Dwayne G.
    PLOS GENETICS, 2020, 16 (01):
  • [24] MAP9 DEFICIENCY SPONTANEOUSLY DRIVES COLON TUMORIGENESIS THROUGH INDUCING CHROMOSOME INSTABILITY
    Wang, Shiyan
    Huang, Junzhe
    Li, Chuangen
    Zhao, Liuyang
    Zhou, Yunfei
    Deng, Wen
    Zeng, Yong
    Wang, Guoping
    Zhang, Yanquan
    Guan, Xin-Yuan
    Wei, Hong
    Wong, Sunny H.
    Shay, Jerry
    Yu, Jun
    GASTROENTEROLOGY, 2019, 156 (06) : S373 - S373
  • [25] Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
    Baergen, Allison K.
    Jeusset, Lucile M.
    Lichtensztejn, Zelda
    McManus, Kirk J.
    CANCERS, 2019, 11 (08)
  • [26] Mechanisms that generate chromosome instability in tumor cells and tumor-like cells expressing pericentrin
    Jurczyk, A
    Pihan, GA
    Doxsey, SJ
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 567A - 567A
  • [27] Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution
    Peng, Chaosheng
    Wang, Juan
    Wang, Shu
    Zhao, Yan
    Wang, Haoyuan
    Wang, Yuhao
    Ma, Yuxuan
    Yang, Jianjun
    CANCER MEDICINE, 2025, 14 (05):
  • [28] Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes
    Ban, Ivana
    Tomasic, Lucija
    Trakala, Marianna
    Tolic, Iva M.
    Pavin, Nenad
    BIOPHYSICAL JOURNAL, 2023, 122 (04) : 632 - 645
  • [29] Examining the selective contribution of chromosomal instability to tumor evolution and prognosis
    Bakhoum, Samuel F.
    Danilova, Olga
    Kaur, Prabhjot
    Levy, Norman
    Thompson, Sarah L.
    Compton, Duane A.
    CANCER RESEARCH, 2012, 72
  • [30] Genetic instability and the evolution of angiogenic tumor cell lines (Review)
    Wodarz, D
    Krakauer, DC
    ONCOLOGY REPORTS, 2001, 8 (06) : 1195 - 1201
12345