Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor-α Inhibitors

被引:56
|
作者
Bradford, Russell D. [1 ]
Pettit, April C. [4 ]
Wright, Patty W. [4 ]
Mulligan, Mark J. [6 ]
Moreland, Larry W. [7 ]
McLain, David A.
Gnann, John W. [1 ,2 ,3 ]
Bloch, Karen C. [4 ,5 ]
机构
[1] Univ Alabama, Dept Pediat, Div Infect Dis, Birmingham, AL 35233 USA
[2] Univ Alabama, Dept Med, Div Infect Dis, Birmingham, AL 35233 USA
[3] Birmingham VA Med Ctr, Birmingham, AL USA
[4] Vanderbilt Univ, Sch Med, Div Infect Dis, Dept Med, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA
[6] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA
[7] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15260 USA
基金
美国国家卫生研究院;
关键词
POLYMERASE-CHAIN-REACTION; RHEUMATOID-ARTHRITIS; CEREBROSPINAL-FLUID; VIRUS ENCEPHALITIS; INFECTIONS; MANAGEMENT; DIAGNOSIS; THERAPY; RISK;
D O I
10.1086/605498
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.
引用
收藏
页码:924 / 927
页数:4
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