The -44 C/G (rs1800972) polymorphism of the β-defensin 1 is associated with increased risk of developing type 2 diabetes mellitus

被引:3
|
作者
Antonio Martinez-Rios, Marco [1 ]
Vargas-Alarcon, Gilberto [2 ]
Antonio Pena-Duque, Marco [1 ]
Perez-Mendez, Oscar [2 ]
Manuel Rodriguez-Perez, Jose [2 ]
Perez-Hernandez, Nonanzit [2 ]
Herrera-Maya, Gabriel [2 ]
Posadas-Sanchez, Rosalinda [3 ]
Posadas-Romero, Carlos [3 ]
Manuel Fragoso, Jose [2 ]
机构
[1] Inst Nacl Cardiol Ignacio Chavez, Intervent Cardiol, Mexico City, DF, Mexico
[2] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico
[3] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City, DF, Mexico
来源
关键词
diabetes; genomics; susceptibility; beta-defensin; 1; EXPRESSION; MACROPHAGES; INSULIN; GENE; BETA-DEFENSIN-1; APOPTOSIS; IMMUNITY; GLUCOSE; INNATE; CELLS;
D O I
10.1002/mgg3.509
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background The aim of this study was to establish the association of two polymorphisms of the beta-defensin 1 gene (DEFB1, OMIM#602056) with the risk of developing type 2 diabetes mellitus (T2DM) in a group of Mexican patients. Methods The 5 ' UTR -20 G/A, and -44 C/G polymorphisms of DEFB1 gene were genotyped by 5 ' exonuclease TaqMan assays in a group of 252 patients with T2DM and 522 healthy control. Results Under dominant and additive models adjusted for the risk factors, the C allele of the -44 C/G polymorphism was associated with increased risk of T2DM (OR = 1.63, 95% CI = 1.07-2.48, pC(dom) = 0.021 and OR = 1.42, 95% CI = 1.05-1.91, pC(add) = 0.023, respectively). In addition, the linkage disequilibrium analysis showed that AC haplotype was associated with an increased risk of developing T2DM (OR = 4.39, p = 0.04). The in-silico analysis showed that the -44 C allele produces a binding site for the transcription factor Ikaros (IK). Conclusion This study demonstrates that the C allele of -44 C/G polymorphism, as well as haplotype AC are associated with the presence of T2DM in the Mexican population. The variation in this polymorphism of the DEFB1 gene could increase the migration of the macrophages to pancreatic islets accelerate the beta-cell dysfunction in T2DM.
引用
收藏
页数:7
相关论文
共 50 条
  • [21] The rs2292239 polymorphism in ERBB3 gene is associated with risk for type 1 diabetes mellitus in a Brazilian population
    Lemos, Natalia Emerim
    Dieter, Cristine
    Dorfman, Luiza Emy
    Assmann, Tais Silveira
    Kullmann Duarte, Guilherme Coutinho
    Canani, Luis Henrique
    Bauer, Andrea Carla
    Crispim, Daisy
    GENE, 2018, 644 : 122 - 128
  • [22] The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children
    Tianyou Yang
    Zhuorong Zhang
    Jiao Zhang
    Tianbao Tan
    Jiliang Yang
    Jing Pan
    Chao Hu
    Jiahao Li
    Huimin Xia
    Jing He
    Yan Zou
    BMC Cancer, 18
  • [23] The MCP-1 Gene A-2518G Polymorphism Confers an Increased Risk of Vascular Complications in Type 2 Diabetes Mellitus Patients
    Xu, Jin
    Liao, Yun-Fei
    Zhou, Wei-Ping
    Ming, Hua-Li
    Wang, Qing-Hai
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2015, 19 (08) : 411 - 417
  • [24] The NLRP3 inflammasome rs35829419 C>A polymorphism is associated with type 2 diabetes mellitus in Saudi Arabia
    Kaabi, Yahia A.
    SAUDI MEDICAL JOURNAL, 2023, 44 (08) : 745 - 750
  • [25] MTNR 1B (rs10830963) Gene Polymorphism, but not MTNR 1A (rs2119882), Associated with Type 2 Diabetes Mellitus Risk in Saudi Arabia
    Kaabi, Yahia A.
    CLINICAL LABORATORY, 2024, 70 (01) : 133 - 138
  • [26] Hematopoietically expressed homeobox (HHEX) gene polymorphism (rs5015480) is associated with increased risk of gestational diabetes mellitus
    Tarnowski, M.
    Malinowski, D.
    Safranow, K.
    Dziedziejko, V.
    Czerewaty, M.
    Pawlik, A.
    CLINICAL GENETICS, 2017, 91 (06) : 843 - 848
  • [27] Genetic polymorphism of interleukin-1β is associated with risk of type 1 diabetes mellitus in children
    Krikovszky, D
    Vásárhelyi, B
    Treszl, A
    Körner, A
    Tordai, A
    Tulassay, T
    Madácsy, L
    EUROPEAN JOURNAL OF PEDIATRICS, 2002, 161 (09) : 507 - 508
  • [28] Genetic polymorphism of interleukin-1β is associated with risk of type 1 diabetes mellitus in children
    Dóra Krikovszky
    Barna Vásárhelyi
    András Treszl
    Anna Körner
    Attila Tordai
    Tivadar Tulassay
    László Madácsy
    European Journal of Pediatrics, 2002, 161 : 507 - 508
  • [29] The rs2442598 polymorphism in the ANGPT-2 gene is associated with risk for diabetic retinopathy in patients with type 1 diabetes mellitus in a Brazilian population
    Dieter, Cristine
    Lemos, Natalia Emerim
    de Faria Correa, Nathalia Rodrigues
    Costa, Aline Rodrigues
    Canani, Luis Henrique
    Crispim, Daisy
    Bauer, Andrea Carla
    ARCHIVES OF ENDOCRINOLOGY METABOLISM, 2021, 65 (06): : 794 - 800
  • [30] Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals
    Liu, L.
    Ding, H.
    Wang, H. R.
    Xu, Y. J.
    Cui, G. L.
    Wang, P. H.
    Yuan, G.
    Yu, X. F.
    Wang, D. W.
    DIABETOLOGIA, 2012, 55 (06) : 1685 - 1688