Biomimetic Total Synthesis of Angelicoin A and B via a Palladium-Catalyzed Decarboxylative Prenylation-Aromatization Sequence

被引：34

作者：

Anderson, Katie ^{[1
]}

Calo, Frederick ^{[1
]}

Pfaffeneder, Toni ^{[1
]}

White, Andrew J. P. ^{[1
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

CONVERGENT SYNTHESIS; NATURAL-PRODUCTS; DERIVATIVES; ALLYLATION; COMPLEXES; LACTONES; ACIDS;

D O I：

10.1021/ol202320m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five-step total syntheses of angelicoin A and B from 2,2,6-trimethyl-4-dioxinone are reported using late stage biomimetic aromatization reactions via diketo-dioxinones as intermediates. In addition, with angelicoin A, this aromatization was coupled with a palladium-catalyzed decarboxylative prenylation in a one-pot sequence as the key step.

引用

页码：5748 / 5750

页数：3

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