Regional differences in the in vitro penetration of methylsalicylate through equine skin

被引:4
|
作者
Mills, P. C. [1 ]
Cross, S. E.
机构
[1] Univ Queensland, Sch Vet Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Princess Alexandra Hosp, Therapeut Res Unit, So Clin Div, Brisbane, Qld 4102, Australia
来源
VETERINARY JOURNAL | 2007年 / 173卷 / 01期
关键词
horse; transdermal methylsalicylate; salicylate; in vitro;
D O I
10.1016/j.tvjl.2005.08.023
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Commercial formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are developed for human use but the extent to which they will pass through equine skin is unknown. Skin was harvested from five Thoroughbred geldings from the thorax, groin and leg (dorsal metacarpal) regions and frozen (-20 degrees C) until required. Two grams of methylsalicylate (Mesa) gel was applied to defrosted full-thickness samples in diffusion cells and the penetration of Mesa and its active metabolite, salicylate (Sa), through skin samples were measured over 24 h. Significantly higher (P <= 0.02) total salicylate (AUC; Mesa + Sa) penetrated through skin from the leg region (5491.3 h mg/L), compared to thorax (3710.7 h mg/L) and groin (3571.5 h mg/L). In addition, there was a significantly higher (P <= 0.01) rate of penetration of total Sa through leg skin in the first 6 It after application. It was concluded that the commercial formulation of Mesa would achieve therapeutic levels of total salicylate beneath sites of topical application, with a faster and more pronounced response through the leg region, compared to the upper body. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:57 / 61
页数:5
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